Journal ArticleDOI
Effect of the size of biodegradable microparticles on drug release: experiment and theory.
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TLDR
Investigation of the effect of the size of biodegradable microparticles (monolithic dispersions) on the release rate of an incorporated drug in a quantitative way revealed that the degradation behavior of the matrix forming polymer was not significantly affected by the sizes of the devices and that autocatalytic effects do not seem to play a major role.About:
This article is published in Journal of Controlled Release.The article was published on 2004-04-16. It has received 264 citations till now. The article focuses on the topics: Controlled release & Microparticle.read more
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Mathematical modeling of drug delivery.
TL;DR: An overview on the current state of the art of mathematical modeling of drug delivery, including empirical/semi-empirical and mechanistic realistic models is given, Analytical as well as numerical solutions are described and various practical examples are given.
Journal ArticleDOI
Polymersomes for drug delivery: Design, formation and characterization
Jung Seok Lee,Jan Feijen +1 more
TL;DR: Recent advances of Ps as drug delivery systems are discussed, and preparative methods and characterization techniques for Ps, protein and cell interactions with Ps, in vivo circulation kinetics and biodistribution are addressed.
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Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems
TL;DR: This article aims to provide a comprehensive review of existing mathematical models and simulations of drug release from polymeric microspheres and of drug transport in adjacent tissues and to evaluate the application of existing models to nanoscale drug delivery systems specifically for hydrophobic and hydrophilic molecules.
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A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system.
TL;DR: In this paper, a review of the most important developments in the field of drug dissolution from a historical point of view is presented, which is structured in a chronological order, from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the more recent development in the framework of the Biopharmaceutics Classification System (BCS).
Historical Perspectives A century of dissolution research: From Noyes and Whitney to the Biopharmaceutics Classification System
TL;DR: This review attempts to account the most important developments in the field of dissolution research, from a historical point of view, in the framework of the Biopharmaceutics Classification System (BCS).
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Journal ArticleDOI
Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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Rate of release of medicaments from ointment bases containing drugs in suspension
TL;DR: An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.
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Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
TL;DR: A pH gradient is shown, with the most acidic environment at the center of the spheres and higher pH near the edges, which is characteristic of diffusion-controlled release of the acidicdegradation products.
Journal ArticleDOI
Mathematical modeling of bioerodible, polymeric drug delivery systems.
Juergen Siepmann,Achim Göpferich +1 more
TL;DR: An introduction into mathematical modeling approaches of bioerodible controlled drug delivery systems and to present the most important erosion theories reported in the literature are given.