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Nathalie Matter
Researcher at Karlsruhe Institute of Technology
Publications - 4
Citations - 696
Nathalie Matter is an academic researcher from Karlsruhe Institute of Technology. The author has contributed to research in topics: RNA splicing & Alternative splicing. The author has an hindex of 4, co-authored 4 publications receiving 660 citations.
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Signal-dependent regulation of splicing via phosphorylation of Sam68
TL;DR: The nuclear RNA-binding protein Sam68 is a new extracellular signal-regulated kinase (ERK) target that binds exonic splice-regulatory elements of an alternatively spliced exon that is physiologically regulated by the Ras signalling pathway, namely exon v5 of CD44.
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Splicing Segregation: The Minor Spliceosome Acts outside the Nucleus and Controls Cell Proliferation
TL;DR: By selectively interfering with snRNA function in zebrafish development and in mammalian cells, it is argued that the segregation of the splicing systems allows for processing of partially unspliced cytoplasmic transcripts, emerging as a result of different splicing rates.
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Heterogeneous ribonucleoprotein A1 is part of an exon-specific splice-silencing complex controlled by oncogenic signaling pathways.
TL;DR: The results define hnRNP A1 as a decisive part of an oncogene-regulated splice-silencing complex, which can select between multiple alternatively spliced exons.
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Targeted ‘knockdown’ of spliceosome function in mammalian cells
Nathalie Matter,Harald König +1 more
TL;DR: It is shown that morpholino oligomers complementary to the branch-site recognition elements of U2 or U12 small nuclear RNA specifically suppress the function of the two splicing systems in mammalian cells.