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Nathalie Vega
Researcher at Claude Bernard University Lyon 1
Publications - 31
Citations - 2725
Nathalie Vega is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Adipose tissue & Insulin. The author has an hindex of 19, co-authored 30 publications receiving 2572 citations. Previous affiliations of Nathalie Vega include Institut national des sciences Appliquées de Lyon & French Institute of Health and Medical Research.
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Journal ArticleDOI
Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism A NOVEL REGULATORY MECHANISM ALTERED IN OBESITY
Daniel Bach,Sara Pich,Francesc X. Soriano,Nathalie Vega,Bernhard Baumgartner,Josep Oriola,Jens R. Daugaard,Jorge Lloberas,Marta Camps,Juleen R. Zierath,Rémi Rabasa-Lhoret,Harriet Wallberg-Henriksson,Martine Laville,Manuel Palacín,Hubert Vidal,Francisca Rivera,Martin D. Brand,Antonio Zorzano +17 more
TL;DR: It is shown that Mfn2 (mitofusin 2), a mitochondrial membrane protein that participates in mitochondrial fusion in mammalian cells, is induced during myogenesis and contributes to the maintenance and operation of the mitochondrial network.
Journal ArticleDOI
Depot-Specific Differences in Adipose Tissue Gene Expression in Lean and Obese Subjects
Anne-Marie Lefebvre,Martine Laville,Nathalie Vega,Jean-Paul Riou,L van Gaal,Johan Auwerx,Hubert Vidal +6 more
TL;DR: Peroxisome proliferator activated receptor-γ mRNA levels were significantly lower in visceral adipose tissue in subjects with a BMI <30 kg/m2, but not in obese subjects, indicating that relative PPAR-γ expression is increased in omental fat in obesity.
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Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor α and Interleukin-6
Daniel Bach,Deborah Naon,Sara Pich,Francesc X. Soriano,Nathalie Vega,Jennifer Rieusset,Martine Laville,Christelle Guillet,Yves Boirie,Harriet Wallberg-Henriksson,Melania Manco,Menotti Calvani,Marco Castagneto,Manuel Palacín,Geltrude Mingrone,Juleen R. Zierath,Hubert Vidal,Antonio Zorzano +17 more
TL;DR: In vivo modulation of Mfn2 mRNA levels is an additional level of regulation for the control of muscle metabolism and could provide a molecular mechanism for alterations in mitochondrial function in obesity or type 2 diabetes.
Journal ArticleDOI
Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue Evidence for Specific Defects in Type 2 Diabetes
Pierre-Henri Ducluzeau,Noël Perretti,Martine Laville,Fabrizio Andreelli,Nathalie Vega,Jean-Paul Riou,Hubert Vidal +6 more
TL;DR: Evidence is provided for a specific defect in the regulation of a group of important genes in response to insulin in peripheral tissues of type 2 diabetic patients.
Journal ArticleDOI
Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle.
TL;DR: An acute coordinated regulation by insulin of the expression of genes coding key proteins involved in its action in human skeletal muscle is demonstrated and it is suggested that Rad and the p85alpha regulatory subunit of phosphatidylinositol-3-kinase can be added to the list of the genes controlled by insulin.