N
Nathaniel D. Tippens
Researcher at Cornell University
Publications - 20
Citations - 774
Nathaniel D. Tippens is an academic researcher from Cornell University. The author has contributed to research in topics: Enhancer & Promoter. The author has an hindex of 9, co-authored 19 publications receiving 510 citations. Previous affiliations of Nathaniel D. Tippens include Johns Hopkins University School of Medicine & Wyss Institute for Biologically Inspired Engineering.
Papers
More filters
Journal ArticleDOI
Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis
Yen-Sin Ang,Renee N. Rivas,Alexandre J.S. Ribeiro,Rohith Srivas,Janell Rivera,Nicole Stone,Karishma Pratt,Tamer M.A. Mohamed,Ji-Dong Fu,C. Ian Spencer,Nathaniel D. Tippens,Molong Li,Anil Narasimha,Ethan Radzinsky,Anita J. Moon-Grady,Haiyuan Yu,Beth L. Pruitt,Michael Snyder,Deepak Srivastava +18 more
TL;DR: Results reveal how disease-causing missense mutations can disrupt transcriptional cooperativity, leading to aberrant chromatin states and cellular dysfunction, including those related to morphogenetic defects.
Journal ArticleDOI
Nascent RNA analyses: tracking transcription and its regulation
TL;DR: This Review provides an overview of different approaches for measuring nascent RNA synthesis and discusses the complementary strengths of these different methods and how they have contributed to a mechanistic understanding of transcription regulation.
Journal ArticleDOI
Enhancer transcription: what, where, when, and why?
TL;DR: A general unified model to explain possible functions of transcription at enhancers is proposed, and bidirectional transcription from promoters is associated with enhancer activity, lending further credence to models in which regulatory elements exist along a spectrum of promoter-ness and enhancers.
Journal ArticleDOI
Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers.
TL;DR: These results suggest that promoter- and enhancer-associated Pol II is a regulatory nexus for integrating information across TSS ensembles and provide a framework for understanding genome regulatory architecture.
Journal ArticleDOI
Transcription imparts architecture, function and logic to enhancer units.
Nathaniel D. Tippens,Jin Liang,Alden King-Yung Leung,Shayne D. Wierbowski,Abdullah Ozer,James G. Booth,John T. Lis,Haiyuan Yu +7 more
TL;DR: It is shown that active enhancer units are precisely delineated by active transcription start sites, validated that these boundaries are sufficient for capturing enhancer function, and confirmed that core promoter sequences are necessary for this activity.