N
Neal R. Cutler
Researcher at National Institutes of Health
Publications - 183
Citations - 7124
Neal R. Cutler is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Placebo & Tolerability. The author has an hindex of 41, co-authored 183 publications receiving 6879 citations. Previous affiliations of Neal R. Cutler include University of Utah & University of Virginia.
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Journal ArticleDOI
Positron emission tomography in Alzheimer's disease
Ranjan Duara,Cheryl L. Grady,James V. Haxby,Magesh Sundaram,Neal R. Cutler,Leonard L. Heston,Angela M. Moore,Nicholas L. Schlageter,Steven M. Larson,Stanley I. Rapoport +9 more
TL;DR: PET is useful in quantifying regional cerebral dysfunction in DAT, even in the early stages of the disease, and reduces in ratio measures of relative metabolism in some parietal, temporal, and frontal regions were found.
Journal ArticleDOI
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.
Neil C. Bodick,Walter W. Offen,Allan I. Levey,Neal R. Cutler,Serge Gauthier,Andrew Satlin,Harlan E. Shannon,Gary D. Tollefson,Kurt Rasmussen,Frank P. Bymaster,Daniel J. Hurley,William Z. Potter,Steven M. Paul +12 more
TL;DR: The observed improvements in ADAS-Cog and CIBIC+ following treatment with xanomeline provide the first evidence, from a large-scale, placebo-controlled clinical trial, that a direct-acting muscarinic receptor agonist can improve cognitive function in patients with AD.
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Relations between Neuropsychological and Cerebral Metabolic Asymmetries in Early Alzheimer's Disease
TL;DR: The results demonstrate that discrepancies between language and visuospatial deficits in patients with early AD are related to asymmetrical reductions in cerebral cortical glucose metabolism.
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Human brain glucose utilization and cognitive function in relation to age
Ranjan Duara,Cheryl L. Grady,James V. Haxby,D. H. Ingvar,Louis Sokoloff,Richard Margolin,Ronald G. Manning,Neal R. Cutler,Stanley I. Rapoport +8 more
TL;DR: The results indicate that brain oxidative metabolism, when measured under resting conditions with reduced sensory input, is not reduced in relation to age in healthy men and no significant relations between intelligence and resting cerebral metabolism are evident.
Journal ArticleDOI
Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years.
Ranjan Duara,Richard Margolin,Elizabeth A. Robertson-tchabo,Edythe D. London,Michael Schwartz,J. W. Renfrew,B. J. Koziarz,Magesh Sundaram,Cheryl L. Grady,Angela M. Moore,D. H. Ingvar,Louis Sokoloff,Herbert Weingartner,R. M. Kessler,Ronald G. Manning,Michael A. Channing,Neal R. Cutler,Stanley I. Rapoport +17 more
TL;DR: The results indicate that the cerebral metabolic rate for glucose is not correlated with age in healthy men.