K
Kurt Rasmussen
Researcher at Eli Lilly and Company
Publications - 83
Citations - 5922
Kurt Rasmussen is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Locus coeruleus & Dopamine. The author has an hindex of 41, co-authored 82 publications receiving 5570 citations. Previous affiliations of Kurt Rasmussen include Yale University.
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Journal ArticleDOI
Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease.
Neil C. Bodick,Walter W. Offen,Allan I. Levey,Neal R. Cutler,Serge Gauthier,Andrew Satlin,Harlan E. Shannon,Gary D. Tollefson,Kurt Rasmussen,Frank P. Bymaster,Daniel J. Hurley,William Z. Potter,Steven M. Paul +12 more
TL;DR: The observed improvements in ADAS-Cog and CIBIC+ following treatment with xanomeline provide the first evidence, from a large-scale, placebo-controlled clinical trial, that a direct-acting muscarinic receptor agonist can improve cognitive function in patients with AD.
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Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices
TL;DR: In this paper, the authors used a modified artificial cerebrospinal fluid (ACSF) in which NaCl was replaced initially by sucrose; the modified ACSF was used during 1) preparation and 2) a 1 hr recovery period.
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Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates
TL;DR: Data suggest that increased neuronal activity in the LC is associated temporally with the behavioral morphine withdrawal syndrome and that increased levels of G- proteins and an up-regulated cAMP system may contribute to the early withdrawal activation of these neurons.
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Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor
Masaaki Iwata,Kristie T. Ota,Xiaoyuan Li,Fumika Sakaue,Nanxin Li,Sophie Dutheil,Mounira Banasr,Vanja Duric,Vanja Duric,Takehiko Yamanashi,Koichi Kaneko,Kurt Rasmussen,Andrew L. Glasebrook,Anja Koester,Dekun Song,Kenneth A. Jones,Stevin H. Zorn,Gennady N. Smagin,Ronald S. Duman +18 more
TL;DR: These findings demonstrate that psychological "stress" is sensed by the innate immune system in the brain via the ATP/P2X7R-NLRP3 inflammasome cascade, and they identify novel therapeutic targets for the treatment of stress-related mood disorders and comorbid illnesses.
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High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation
TL;DR: The results show that a high-fat diet (HFD; ~16 weeks) causes anxiety and anhedonic behaviors, and pharmacological blockade of the innate immune inflammasome system by repeated administration of an inhibitor of the purinergic P2X7 receptor blocks the anxiety caused by HFD.