N
Neha Quadir
Researcher at Indian Council of Medical Research
Publications - 4
Citations - 65
Neha Quadir is an academic researcher from Indian Council of Medical Research. The author has contributed to research in topics: Autophagy & Innate immune system. The author has an hindex of 2, co-authored 4 publications receiving 9 citations. Previous affiliations of Neha Quadir include Jamia Hamdard.
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Journal ArticleDOI
Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation.
Mohd Shariq,Neha Quadir,Neha Quadir,Neha Sharma,Neha Sharma,Jasdeep Singh,Javaid A. Sheikh,Mohd Khubaib,Seyed E. Hasnain,Seyed E. Hasnain,Seyed E. Hasnain,Nasreen Z. Ehtesham +11 more
TL;DR: RipA (Rv1477), a peptidoglycan hydrolase, has been shown to activate the NFκB signaling pathway and elicits the production of pro-inflammatory cytokines, TNF-α, IL-6, and IL-12, through the activation of an innate immune-receptor, toll-like receptor (TLR)4 as mentioned in this paper.
Journal ArticleDOI
Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival.
Neha Sharma,Neha Sharma,Mohd Shariq,Neha Quadir,Neha Quadir,Jasdeep Singh,Javaid A. Sheikh,Seyed E. Hasnain,Seyed E. Hasnain,Nasreen Z. Ehtesham +9 more
TL;DR: In this article, the authors show that PE6 protein (Rv0335c) is a secretory protein effector that interacts with TLR4 on the macrophage cell surface and promotes activation of the canonical NF-B signaling pathway to stimulate secretion of proinflammatory cytokines TNF-α, IL-12, and IL-6.
Journal ArticleDOI
Post translational modifications in tuberculosis: ubiquitination paradox
Mohd Shariq,Neha Quadir,Neha Quadir,Javaid A. Sheikh,Alok Kumar Singh,William R. Bishai,Nasreen Z. Ehtesham,Seyed Ehtesham Hasnain +7 more
TL;DR: The co-option of the ubiquitin pathway by the M. tb virulence effectors is discussed and the role of autophagy receptors in this co-optation is discussed.
Journal ArticleDOI
Development and Validation of Signature Sequence-Based PCR for Improved Molecular Diagnosis of Tuberculosis.
Neha Quadir,Neha Quadir,Syed Asad Rahman,Javeed Ahmad,Ayan Kumar Das,Naresh Arora,Javaid A. Sheikh,Neeraj Gupta,Prem Kapur,Mridu Dudeja,Seyed E. Hasnain,Seyed E. Hasnain,Nasreen Z. Ehtesham +12 more
TL;DR: Using extensive comparative bioinformatics approach, this article mined the genome for M. tuberculosis-specific genes and identified four genes so-called signature sequence (SS), which can make a positive impact on case detection rates.