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Neil W. Owens
Researcher at University of Manitoba
Publications - 8
Citations - 121
Neil W. Owens is an academic researcher from University of Manitoba. The author has contributed to research in topics: Isomerization & Conformational isomerism. The author has an hindex of 4, co-authored 8 publications receiving 116 citations.
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Journal ArticleDOI
Contiguous O-galactosylation of 4(R)-hydroxy-l-proline residues forms very stable polyproline II helices.
TL;DR: This study gives further insight into the effects of naturally occurring Hyp beta-O-linked glycans on the PPII conformation as found in HRGPs in plant cell walls and indicates that polyproline sequences may be suitable for the development of molecular scaffolds for the presentation of glycan structures.
Journal ArticleDOI
Effects of Glycosylation of (2S,4R)-4-Hydroxyproline on the Conformation, Kinetics, and Thermodynamics of Prolyl Amide Isomerization
TL;DR: The effects of galactosylation of Hyp on the conformation as well as the thermodynamics and kinetics of prolyl N-terminal amide isomerization are described.
Journal ArticleDOI
Tuning of the prolyl trans/cis-amide rotamer population by use of C-glucosylproline hybrids.
TL;DR: Overall, the GlcProH demonstrates variation in Kt/c through tuning of the carbohydrate scaffold: a new concept in proline peptidomimetics.
Journal ArticleDOI
The implications of (2S,4S)-hydroxyproline 4-O-glycosylation for prolyl amide isomerization.
TL;DR: It was found that the D-galactose residue extending from a C(gamma)-endo pucker affects both K(trans/cis) and the rate of isomerization, which is not found to occur when it is projected from a D-gamma-exo pucker; this reflects the different environments delineated by the proline side chain.
Journal ArticleDOI
Conformational preference of fused carbohydrate-templated proline analogues--a computational study.
Robel B. Teklebrhan,Neil W. Owens,James D. Xidos,Georg Schreckenbach,Stacey D. Wetmore,Frank Schweizer +5 more
TL;DR: The structure of fused C-glucosylproline hybrid (GlcProH) has been studied in detail computationally using the polarizable continuum model (PCM) to predict cis-trans ratios and hydrogen bonding is found to stabilize the cis conformers exclusively.