Nengtai Ouyang

TL;DR: In a more fulminant hepatitis induced by injecting agonistic Fas-specific antibody, 82% of mice treated with siRNA that effectively silenced Fas survived for 10 days of observation, whereas all control mice died within 3 days.

TL;DR: It is suggested that alternatively activated macrophages enhance fibrogenesis of fibroblasts by providing profibrogenic factors, while classically activated Macrophages inhibit fibrogenisation of fibrifying cells by releasing antifibrogensic or fibrolytic factors.

TL;DR: This study confirms the importance of Fas-mediated apoptosis in renal ischemia-reperfusion injury and suggests that silencing Fas by systemic or local catheterization holds therapeutic promise to limit ischemIA-rePerfusions injury.

TL;DR: In human breast cancer xenografts in humanized mice, blocking the recruitment of naive CD4+ T cells into tumor by knocking down the expression of PITPNM3, a CCL18 receptor, significantly reduces intratumoral Tregs and inhibits tumor progression, indicating poor prognosis for breast cancer patients.

TL;DR: Results show that nerve fiber involvement in breast cancer is associated with progression of the malignancy and warrant further studies in the future, and Cox multifactor analysis indicates that the thickness of tumor-involving nerve fibers is a previously unappreciated independent prognostic factors associated with shorter disease-free survival of breast cancer patients.