S
Sang-Kyung Lee
Researcher at Harvard University
Publications - 15
Citations - 3849
Sang-Kyung Lee is an academic researcher from Harvard University. The author has contributed to research in topics: Small interfering RNA & RNA interference. The author has an hindex of 12, co-authored 15 publications receiving 3765 citations. Previous affiliations of Sang-Kyung Lee include Hanyang University.
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Journal ArticleDOI
RNA interference targeting Fas protects mice from fulminant hepatitis
Erwei Song,Sang-Kyung Lee,Jie Wang,Nedim Ince,Nengtai Ouyang,Jun Min,Jisheng Chen,Premlata Shankar,Judy Lieberman +8 more
TL;DR: In a more fulminant hepatitis induced by injecting agonistic Fas-specific antibody, 82% of mice treated with siRNA that effectively silenced Fas survived for 10 days of observation, whereas all control mice died within 3 days.
Journal ArticleDOI
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
Erwei Song,Pengcheng Zhu,Sang-Kyung Lee,Dipanjan Chowdhury,Steven Kussman,Derek M. Dykxhoorn,Yi Feng,Deborah Palliser,David B. Weiner,Premlata Shankar,Wayne A. Marasco,Judy Lieberman +11 more
TL;DR: The potential for systemic, cell-type specific, antibody-mediated siRNA delivery to HIV-infected or envelope-transfected cells is demonstrated and an ErbB2 single-chain antibody fused with protamine delivered siRNAs specifically into ErBB2-expressing cancer cells.
Journal ArticleDOI
siRNA-directed inhibition of HIV-1 infection.
Carl D. Novina,Michael F. Murray,Derek M. Dykxhoorn,Paul J. Beresford,Jonathan W. Riess,Sang-Kyung Lee,Ronald G. Collman,Judy Lieberman,Premlata Shankar,Phillip A. Sharp +9 more
TL;DR: It is reported that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein.
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Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages
Erwei Song,Sang-Kyung Lee,Derek M. Dykxhoorn,Carl D. Novina,Dong Zhang,Keith D. Crawford,Jan Cerny,Phillip A. Sharp,Judy Lieberman,N. Manjunath,Premlata Shankar +10 more
TL;DR: In this paper, the authors investigated if sustained siRNA-mediated silencing of human immunodeficiency virus type 1 (HIV-1) is possible in terminally differentiated macrophages, which constitute an important reservoir of HIV in vivo.
Journal ArticleDOI
Interfering with disease: opportunities and roadblocks to harnessing RNA interference
TL;DR: RNAi could provide an exciting new therapeutic modality for treating infection, cancer, neurodegenerative disease and other illnesses, and can inhibit viral infection and control tumor cell growth in vitro.