Fengxi Su

TL;DR: Let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target, and miRNA expression in self-renewing and differentiated cells from breast cancer lines and in breast T-IC and non-BT-IC from 1 degrees breast cancers is compared.

TL;DR: It is demonstrated that two cell-surface molecules, CD10 and GPR77, specifically define a CAF subset correlated with chemoresistance and poor survival in multiple cohorts of breast and lung cancer patients, and suggested that targeting the CD10+GPR77+ CAFs subset could be an effective therapeutic strategy against CSC-driven solid tumors.

TL;DR: This work identifies an NF-KappaB Interacting LncRNA (NKILA), which is upregulated by NF-κB, binds to NF-σκB/IκBs, and directly masks phosphorylation motifs of IKKB, thereby inhibiting IKK-induced IκBosphorylation and NF-kkB activation.

TL;DR: Macrophages regulate the invasiveness of breast cancer cells through exosome-mediated delivery of oncogenic miRNAs, which provides insight into the mechanisms underlying the metastasis-promoting interactions between macrophages and Breast cancer cells.

TL;DR: It is shown that mesenchymal-like breast cancer cells activate macrophages to a TAM-like phenotype by GM-CSF, which suggests that a positive feedback loop between GM- CSF and CCL18 is important in breast cancer metastasis.