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Neocles B. Leontis
Researcher at Bowling Green State University
Publications - 117
Citations - 11271
Neocles B. Leontis is an academic researcher from Bowling Green State University. The author has contributed to research in topics: RNA & Base pair. The author has an hindex of 47, co-authored 116 publications receiving 10400 citations. Previous affiliations of Neocles B. Leontis include Academy of Sciences of the Czech Republic & Centre national de la recherche scientifique.
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Journal ArticleDOI
The OBO Foundry : coordinated evolution of ontologies to support biomedical data integration
Barry Smith,Michael Ashburner,Cornelius Rosse,Jonathan Bard,William J. Bug,Werner Ceusters,Louis J. Goldberg,Karen Eilbeck,Amelia Ireland,Christopher J. Mungall,Neocles B. Leontis,Philippe Rocca-Serra,Alan Ruttenberg,Susanna-Assunta Sansone,Richard H. Scheuermann,Nigam H. Shah,Patricia L. Whetzel,Suzanna E. Lewis +17 more
TL;DR: This work describes the OBO Foundry initiative and provides guidelines for those who might wish to become involved and describes an expanding family of ontologies designed to be interoperable and logically well formed and to incorporate accurate representations of biological reality.
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Geometric nomenclature and classification of RNA base pairs.
Neocles B. Leontis,Eric Westhof +1 more
TL;DR: This work proposes a classification based on the observation that the planar edge-to-edge, hydrogen-bonding interactions between RNA bases involve one of three distinct edges: the Watson-Crick edge, the Hoogsteen edge, and the Sugar edge, which facilitates the recognition of recurrent three-dimensional motifs from comparison of homologous sequences.
Journal ArticleDOI
The non‐Watson–Crick base pairs and their associated isostericity matrices
TL;DR: This paper presents the 4 x 4 'isostericity matrices' summarizing the geometric relationships between the 16 pairwise combinations of the four standard bases, A, C, G and U, and helps identify isosteric pairs that co-vary or interchange in sequences of homologous molecules while maintaining conserved three-dimensional motifs.
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The building blocks and motifs of RNA architecture.
TL;DR: This work has focused on analyzing RNA backbone conformations to identify, define and search for new instances of recurrent motifs in X-ray structures to identify RNA structural characteristics that are subject to sequence constraints and that thus relate RNA architectures to sequences.
Journal ArticleDOI
Analysis of RNA motifs.
Neocles B. Leontis,Eric Westhof +1 more
TL;DR: It is crucial, when analyzing a three-dimensional RNA structure in order to identify and compare motifs, to first classify its non-Watson-Crick base pairs geometrically.