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Neville E. Sanjana
Researcher at New York University
Publications - 124
Citations - 21164
Neville E. Sanjana is an academic researcher from New York University. The author has contributed to research in topics: CRISPR & Gene. The author has an hindex of 38, co-authored 109 publications receiving 15921 citations. Previous affiliations of Neville E. Sanjana include McGovern Institute for Brain Research & Massachusetts Institute of Technology.
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Patent
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
TL;DR: In this article, a deep scanning mutagenesis library was used to interrogate phenotypi c changes in a population of cells comprising a plurality of CRISPR-Cas system guide RNAs targeting genomic sequences within at least one continuous genomic region.
Patent
Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction
TL;DR: In this article, the nucleic acid molecules target the +62, +58, and/or the +55 enhancer functional regions, and methods for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level.
Journal ArticleDOI
Recurrent somatic mutations as predictors of immunotherapy response
TL;DR: In this article , the Cancer Immunotherapy Response CLassifiEr (CIRCLE) was developed to identify genes and pathways that are significantly mutated following correction for epigenetic, replication timing, and sequence-based covariates.
Posted ContentDOI
High-throughput screens of PAM-flexible Cas9 variants for gene knock-out and transcriptional modulation
Mateusz Legut,Zharko Daniloski,Xinhe Xue,Dayna McKenzie,Xinyi Guo,Hans-Hermann Wessels,Neville E. Sanjana +6 more
TL;DR: A high-throughput Cas9 pooled competition screen is devised to compare the performance of both PAM-flexible Cas9 variants and wild-type Cas9 at thousands of genomic loci and across 3 modalities (gene knock-out, transcriptional activation and suppression).
Posted ContentDOI
Scalable pooled CRISPR screens with single-cell chromatin accessibility profiling
Noa Liscovitch-Brauer,Antonino Montalbano,Jiehui Deng,Alejandro Méndez-Mancilla,Hans-Hermann Wessels,Moss Ng,Kung C,Akash Sookdeo,Xinyi Guo,Evan T. Geller,Suma Jaini,Peter Smibert,Neville E. Sanjana +12 more
TL;DR: A method to link genome-wide chromatin accessibility to genetic perturbations in single cells with a large-scale atlas that correlates loss of specific chromatin remodelers with changes in accessibility — globally and at the binding sites of individual transcription factors.