Suma Jaini

TL;DR: The first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq are taken and system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration is combined.

TL;DR: The data suggest that the regulatory network underlying AR is complex and deeply interconnected with the regulation of GABA and glutamate metabolism, nitrogen metabolism, and the model predicts a novel mechanism for AR1 by which the decarboxylation enzymes of AR2 are used with internally derived glutamate.

TL;DR: A single-cell combinatorial indexing approach for transposase-accessible chromatin (CRISPR-sciATAC) was proposed in this paper, which was applied to human myelogenous leukemia cells.

TL;DR: A protocol for ChIP-Seq tailored for use with mycobacteria and an analysis pipeline for processing the resulting data provide evidence that the long-accepted spatial relationship between TF binding site, promoter motif, and the corresponding regulated gene may be too simple a paradigm, failing to adequately capture the variety of TF binding sites found in prokaryotes.

TL;DR: A method to link genome-wide chromatin accessibility to genetic perturbations in single cells with a large-scale atlas that correlates loss of specific chromatin remodelers with changes in accessibility — globally and at the binding sites of individual transcription factors.