Showing papers by "Nhan Trung Nguyen published in 2015"
TL;DR: This review focuses on recent research on ZNF217-driven molecular functions in human cancers, revisiting major hallmarks of cancer and highlighting the downstream molecular targets and signaling pathways of ZNF 217.
Abstract: The recently described oncogene ZNF217 belongs to a chromosomal region that is frequently amplified in human cancers. Recent findings have revealed that alternative mechanisms such as epigenetic regulation also govern the expression of the encoded ZNF217 protein. Newly discovered molecular functions of ZNF217 indicate that it orchestrates complex intracellular circuits as a new key regulator of tumorigenesis. In this review, we focus on recent research on ZNF217-driven molecular functions in human cancers, revisiting major hallmarks of cancer and highlighting the downstream molecular targets and signaling pathways of ZNF217. We also discuss the exciting translational medicine investigating ZNF217 expression levels as a new powerful biomarker, and ZNF217 as a candidate target for future anti-cancer therapies.
49 citations
TL;DR: A novel and rare 1,4-dehydrated ceramide, embelamide, and a new C-glycoalkaloid which is based on a β- carboline ring system, 1-(2'-deoxy-α-d-ribopyranosyl)-β-carboline (4), were isolated from the CHCl3 soluble fraction of the leaves of Embelia ribes (Myrsinaceae), together with thirteen known compounds.
30 citations
TL;DR: Three new cassane-type furanoditerpenes and 7-acetoxycaesalpinin P, together with seven known compounds, have been isolated from the MeOH extract of the seed kernels of Caesalpinsia bonducella from Vietnam.
5 citations
TL;DR: This chapter briefly summarizes the constituents, biosynthesis, cytotoxicity, and antiausterity activity on PANC-1 human pancreatic cancer cell line of A. altilis.
Abstract: Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. A novel antiausterity strategy in anticancer drug discovery led to the discovery of agents that preferentially inhibit the survival of cancer cells under low nutrient conditions. Artocarpus altilis (Family: Moraceae) is commonly referred to as breadfruit, traditionally for the treatment of many diseases. Many prenylated flavonoid and prenylated chalocones together with their cancer cell cytotoxicity were reported from this plant. This chapter briefly summarizes the constituents, biosynthesis, cytotoxicity, and antiausterity activity on PANC-1 human pancreatic cancer cell line of A. altilis.
4 citations