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Ni Li
Researcher at Chinese Academy of Sciences
Publications - 17
Citations - 821
Ni Li is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 9, co-authored 12 publications receiving 430 citations. Previous affiliations of Ni Li include Shanghai Jiao Tong University.
Papers
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Journal ArticleDOI
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.
Tao Yu,Shucheng Gan,Qingchen Zhu,Dongfang Dai,Ni Li,Ni Li,Hui Wang,Xiaosong Chen,Dan Hou,Yan Wang,Qiang Pan,Qiang Pan,Jing Xu,Xingli Zhang,Junli Liu,Siyu Pei,Chao Peng,Ping Wu,Simona Romano,Chaoming Mao,Mingzhu Huang,Xiao-Dong Zhu,Kunwei Shen,Jun Qin,Jun Qin,Yichuan Xiao +25 more
TL;DR: These findings establish Stat6 acetylation as an essential negative regulatory mechanism that curtails macrophage M2 polarization in both mouse and human macrophages and contributes to pro-tumorigenicmacrophage activity in mice.
Journal ArticleDOI
Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3
Xingli Zhang,Yan Wang,Jia Yuan,Ni Li,Siyu Pei,Jing Xu,Xuan Luo,Chaoming Mao,Junli Liu,Tao Yu,Shucheng Gan,Qianqian Zheng,Yinming Liang,Weixiang Guo,Ju Qiu,Gabriela Constantin,Jin Jin,Jun Qin,Yichuan Xiao +18 more
TL;DR: Ezh2 is established as a macrophage lineage-specific mediator of autoimmune inflammation and highlight a previously unknown mechanism of Ezh2 function.
Journal ArticleDOI
Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis
Huairui Yuan,Ni Li,Da Fu,Jiale Ren,Jingyi Hui,Junjie Peng,Yongfeng Liu,Tong Qiu,Min Jiang,Qiang Pan,Ying Han,Xiaoming Wang,Qintong Li,Jun Qin +13 more
TL;DR: It is found that SETD2 counteracts Wnt signaling and its inactivation promotes intestinal tumorigenesis in mouse models of colorectal cancer (CRC) and ablation reduces intron retention of dishevelled segment polarity protein 2 (DVL2) pre-mRNA, thereby augmenting Wnt signalling.
Journal ArticleDOI
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways.
Huairui Yuan,Ying Han,Xuege Wang,Ni Li,Qiuli Liu,Yuye Yin,Hanling Wang,Lulu Pan,Li Li,Kun Song,Tong Qiu,Qiang Pan,Qilong Chen,Guoying Zhang,Yi Zang,Minjia Tan,Jian Zhang,Qintong Li,Xiaoming Wang,Jun Jiang,Jun Qin,Jun Qin +21 more
TL;DR: It is demonstrated that the SETD2-EZH2 axis integrates metabolic and epigenetic signaling to restrict PCa metastasis and it is identified that metformin-stimulated AMPK signaling converges at FOXO3 to stimulateSETD2 expression.
Journal ArticleDOI
AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis
Ni Li,Wei Xue,Huairui Yuan,Baijun Dong,Yufeng Ding,Yongfeng Liu,Min Jiang,Shan Kan,Tongyu Sun,Jiale Ren,Qiang Pan,Xiang Li,Peiyuan Zhang,Guohong Hu,Yan Wang,Xiaoming Wang,Qintong Li,Jun Qin +17 more
TL;DR: Findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive PCa metastasis.