N
Nicholas J. Donato
Researcher at University of Michigan
Publications - 132
Citations - 9089
Nicholas J. Donato is an academic researcher from University of Michigan. The author has contributed to research in topics: Tyrosine kinase & Chronic myelogenous leukemia. The author has an hindex of 38, co-authored 131 publications receiving 8649 citations. Previous affiliations of Nicholas J. Donato include University of Texas at Austin & University of Texas MD Anderson Cancer Center.
Papers
More filters
Journal ArticleDOI
Dasatinib in Imatinib-Resistant Philadelphia Chromosome–Positive Leukemias
Moshe Talpaz,Neil P. Shah,Hagop M. Kantarjian,Nicholas J. Donato,John Nicoll,Ron Paquette,Jorge E. Cortes,Susan O'Brien,Claude Nicaise,Eric Bleickardt,M. Anne Blackwood-Chirchir,Vishwanath Iyer,Tai-Tsang Chen,Fei Huang,Arthur P. DeCillis,Charles L. Sawyers,Charles L. Sawyers +16 more
TL;DR: Dasatinib induces hematologic and cytogenetic responses in patients with CML or Ph-positive ALL who cannot tolerate or are resistant to imatinib, which is effective in Philadelphia chromosome-positive leukemias but relapse occurs.
Journal ArticleDOI
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.
Nicholas J. Donato,Ji Yuan Wu,Jonathan Stapley,Gary E. Gallick,Hui Kuan Lin,Ralph B. Arlinghaus,Moshe Talpaz +6 more
TL;DR: Comparison of samples from patients taken prior to and following STI571 failure suggested that expression and/or activation of LYN/HCK occurs during disease progression, and results suggest that acquired STi571 resistance may be associated with BCR-ABL independence and mediated in part through overexpression of other tyrosine kinases.
Journal ArticleDOI
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
TL;DR: It is found that curcumin down-regulates NF-κB in human MM cells, leading to the suppression of proliferation and induction of apoptosis, thus providing the molecular basis for the treatment of MM patients with this pharmacologically safe agent.
Journal ArticleDOI
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.
Cristian Bellodi,Maria Rosa Lidonnici,Ashley Hamilton,G. Vignir Helgason,Angela Rachele Soliera,Mattia Ronchetti,Sara Galavotti,Kenneth W. Young,Tommaso Selmi,Rinat Yacobi,Richard A. Van Etten,Nicholas J. Donato,Ann Hunter,David Dinsdale,Elena Tirrò,Paolo Vigneri,Pierluigi Nicotera,Martin J. S. Dyer,Tessa L. Holyoake,Paolo Salomoni,Bruno Calabretta +20 more
TL;DR: The authors showed that IM-induced autophagy did not involve c-Abl or Bcl-2 activity, but was associated with ER stress and was suppressed by depletion of intracellular Ca2+, suggesting it is mechanistically nonoverlapping with IMinduced apoptosis.
Journal ArticleDOI
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.
TL;DR: It is demonstrated that curcumin was a potent inhibitor of STAT3 phosphorylation, and this plays a role in the suppression of MM proliferation.