X
Xiangguo Qiu
Researcher at Public Health Agency of Canada
Publications - 151
Citations - 6994
Xiangguo Qiu is an academic researcher from Public Health Agency of Canada. The author has contributed to research in topics: Ebola virus & Ebolavirus. The author has an hindex of 43, co-authored 142 publications receiving 5981 citations. Previous affiliations of Xiangguo Qiu include National Microbiology Laboratory & Peking University.
Papers
More filters
Journal ArticleDOI
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
Xiangguo Qiu,Gary Wong,Jonathan Audet,Alexander Bello,Lisa Fernando,Judie B. Alimonti,Hugues Fausther-Bovendo,Haiyan Wei,Jenna Aviles,Ernie Hiatt,Ashley K. Johnson,Josh Morton,Kelsi Swope,Ognian Bohorov,Natasha Bohorova,Charles Goodman,Do Jin Kim,Michael H. Pauly,Jesus Velasco,James Pettitt,Gene G. Olinger,Kevin J. Whaley,Bianli Xu,James E. Strong,Larry Zeitlin,Gary P. Kobinger +25 more
TL;DR: It is shown that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge, and ZMapp exceeds the efficacy of any other therapeutics described so far.
Journal ArticleDOI
Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies
Xiangguo Qiu,Jonathan Audet,Gary Wong,Stéphane Pillet,Alexander Bello,Teresa Cabral,Jim Strong,Frank Plummer,Cindy R. Corbett,Cindy R. Corbett,Judie B. Alimonti,Judie B. Alimonti,Gary P. Kobinger,Gary P. Kobinger +13 more
TL;DR: The present work shows that a combination of three neutralizing monoclonal antibodies directed against the Ebola envelope glycoprotein (GP) resulted in complete survival (four of four cynomolgus macaques) with no apparent side effects when three doses were administered 3 days apart beginning at 24 hours after a lethal challenge with EBOV.
Journal ArticleDOI
Nanozyme-strip for rapid local diagnosis of Ebola.
Demin Duan,Kelong Fan,Dexi Zhang,Shuguang Tan,Mifang Liang,Yang Liu,Jianlin Zhang,Panhe Zhang,Wei Liu,Xiangguo Qiu,Gary P. Kobinger,George F. Gao,Xiyun Yan +12 more
TL;DR: In this article, the authors used Fe3O4 magnetic nanoparticles (MNP) as a nano-probe to detect the glycoprotein of Ebola virus (EBOV) as low as 1 ng/mL, which is 100 times more sensitive than the standard strip method.
Supplementary Materials for Nanozyme-strip for rapid local diagnosis of Ebola
Demin Duan,Kelong Fan,Dexi Zhang,Shuguang Tan,Mifang Liang,Yang Liu,Jianlin Zhang,Panhe Zhang,Wei Liu,Xiangguo Qiu,Gary P. Kobinger,George Fu Gao,Xiyun Yan +12 more
TL;DR: A MNP-based immunochromatographic strip (Nanozyme-strip), which detects the glycoprotein of Ebola virus (EBOV) as low as 1 ng/mL, which is 100-fold more sensitive than the standard strip method.
Journal ArticleDOI
Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Qihui Wang,Huabing Yang,Huabing Yang,Xiaoqing Liu,Lianpan Dai,Tong Ma,Tong Ma,Jianxun Qi,Gary Wong,Ruchao Peng,Sheng Liu,Sheng Liu,Junfu Li,Shihua Li,Jian Song,Jianying Liu,Jianhua He,Hui Yuan,Ying Xiong,Yong Liao,Jianhua Li,Jianping Yang,Zhou Tong,Bryan D. Griffin,Bryan D. Griffin,Yuhai Bi,Mifang Liang,Xiao-Ning Xu,Chuan Qin,Gong Cheng,Xinzheng Zhang,Peiyi Wang,Xiangguo Qiu,Xiangguo Qiu,Gary P. Kobinger,Yi Shi,Jinghua Yan,George F. Gao +37 more
TL;DR: The isolation of 13 specific human monoclonal antibodies from a patient infected with Zika virus suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.