R
Robert A. Davey
Researcher at Texas Biomedical Research Institute
Publications - 104
Citations - 6272
Robert A. Davey is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Ebola virus & Virus. The author has an hindex of 39, co-authored 91 publications receiving 5542 citations. Previous affiliations of Robert A. Davey include Boston University & Royal North Shore Hospital.
Papers
More filters
Journal ArticleDOI
Biochemical evidence that Patched is the Hedgehog receptor
TL;DR: Binding studies using labelled Shh that strongly suggest that the Hh receptor is encoded by patched (ptc), a gene first identified in genetic screens in Drosophila4.
Journal ArticleDOI
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
Yasuteru Sakurai,Andrey A. Kolokoltsov,Cheng-Chang Chen,Michael W. Tidwell,William E. Bauta,Norbert Klugbauer,Christian Grimm,Christian Wahl-Schott,Martin Biel,Robert A. Davey +9 more
TL;DR: It is found that Ebola virus entry into host cells requires the endosomal calcium channels called two-pore channels called TPCs, and disrupting TPC function by gene knockout, small interfering RNAs, or small-molecule inhibitors halted virus trafficking and prevented infection.
Journal ArticleDOI
Cellular Entry of Ebola Virus Involves Uptake by a Macropinocytosis-Like Mechanism and Subsequent Trafficking through Early and Late Endosomes
TL;DR: Inhibition of key regulators of macropinocytosis including Pak1 and CtBP/BARS as well as treatment with the drug EIPA resulted in significant reduction in ZEBOV entry and infection, and provides potential insight into the trafficking and entry mechanism of other filoviruses.
Journal ArticleDOI
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus
Andrew S. Kondratowicz,Nicholas J. Lennemann,Patrick L. Sinn,Robert A. Davey,Catherine L. Hunt,Sven Moller-Tank,David K. Meyerholz,Paul D. Rennert,Robert F. Mullins,Melinda A. Brindley,Lindsay M Sandersfeld,Kathrina Quinn,Melodie L. Weller,Paul B. McCray,John A. Chiorini,Wendy Maury +15 more
TL;DR: It is shown that T-cell Ig and mucin domain 1 (TIM-1) binds to the receptor binding domain of the Zaire Ebola virus (EBOV) glycoprotein, and ectopic TIM-1 expression in poorly permissive cells enhances EBOV infection by 10- to 30-fold.
Journal ArticleDOI
A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents
Peter B. Madrid,Sidharth Chopra,Ian D. Manger,Lynne Gilfillan,Tiffany R. Keepers,Amy C. Shurtleff,Carol E. Green,Lalitha V. Iyer,Holli Hutcheson Dilks,Robert A. Davey,Andrey A. Kolokoltsov,Ricardo Carrion,Jean L. Patterson,Sina Bavari,Rekha G. Panchal,Travis K. Warren,Jay Wells,Walter H. Moos,RaeLyn L. Burke,Mary J. Tanga +19 more
TL;DR: The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.