Showing papers in "American Journal of Ophthalmology in 2007"

TL;DR: In this paper, an optical coherence tomography (OCT)-guided, variable-dosing regimen with intravitreal ranibizumab for the treatment of patients with age-related macular degeneration (AMD) was evaluated.

TL;DR: In this paper, the authors evaluated the impact of dry eye syndrome (DES) on vision-associated quality of life and found that those with DES were more likely to report problems with reading, driving, working at the computer, their professional activity, and watching television.

TL;DR: Interferon beta-1b 250 mug subcutaneously every other day delayed conversion to clinically definite multiple sclerosis, and should be considered as a therapeutic option in patients presenting with a first clinical event suggestive of multiple sclerosis.

TL;DR: The results indicate that distinct phenotypic FAF patterns have an impact on disease progression in eyes with atrophic AMD and may therefore serve as prognostic determinants.

TL;DR: In Japanese patients with neovascular AMD, there is a preponderance of PCV, male gender, unilaterality, and absence of drusen in the second eye, with the exception of RAP.

TL;DR: It is reported that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD.

TL;DR: Measurement of IOP with PDCT appears to be relatively immune to changes in corneal biomechanics and pachymetry after LASIK, in comparison to GAT and ORA measures of I Op, which showed statistically lower variation in measurement than GAT.

TL;DR: The ANCHOR study as discussed by the authors showed that the most important predictors of VA outcomes were, in decreasing order of impact, the patient's baseline VA score, CNV lesion size, and age.

TL;DR: Nonvalved tube shunt surgery was more likely to maintain IOP control and avoid persistent hypotony or reoperation for glaucoma than trabeculectomy with MMC during the first year of follow-up in the TVT Study.

TL;DR: There were a large number of surgical complications during the first year of follow-up in the study, but most were self-limited.

TL;DR: The incorporation of a time component in electronic monitoring provides more information than prescription refill rate or other methods and it is found that more complex dosing regimens result in poorer adherence, although once-daily drugs in acomplex dosing regimen were found to have good adherence.

TL;DR: The data demonstrates that a tiered screening strategy combining allele-specific detection with automated DNA sequencing can increase the efficiency of autosomal recessive mutation detection four-fold when compared with DNA sequencing alone.

TL;DR: SICS is significantly faster, less expensive, and less technology dependent than phacoemulsification, and may be the more appropriate surgical procedure for the treatment of advanced cataracts in the developing world.

TL;DR: In this paper, OCT scans revealed that the foveoschisis was associated with macular anomalies: a premacular structure in 13 (44.8%) of 29 eyes, a foveal detachment in 10 (34.5%), and a lamellar macular hole in six (20.7%).

TL;DR: The DALK big-bubble technique is a valuable treatment in patients with keratoconus and visual outcome is comparable to standard penetrating keratoplasty (PK) when formation of big- bubble with exposure of the Descemet membrane (DM) was achieved.

TL;DR: In this article, the authors evaluated visual task performance in three blind subjects implanted with epiretinal prostheses and found that the prosthesis was wirelessly controlled by a computer or by a head-worn video camera.

TL;DR: Lens extraction holds promise not only to improve on the condition of the cataract eye, but also to improved on the age-normal eye, quite independently from visual acuity.

TL;DR: Low-dose aspirin increases the risk of major bleeding by approximately 70%, but the absolute increase is modest: 769 patients (95% CI, 500-1250) need to be treated with aspirin to cause one additional major bleeding episode annually, compared with over 1 million dollars with clopidogrel.

TL;DR: Persistent attachment of the posterior vitreous cortex to the macula may be another risk factor for the development of exudative AMD via vitreoretinal traction inducing chronic low-grade inflammation, by maintaining macular exposure to cytokines or free radicals in the vitreomacular gel, or by interfering in transvitreous oxygenation and nutrition of the Macula.

TL;DR: After five years, intracorneal ring segments implantation improved UCVA, BSCVA, and refraction in the majority of the keratoconus patients, and there was no evidence of progressive sight-threatening complications in this study.

TL;DR: A significant reduction of choriocapillaris endothelial cell fenestrations is seen as early as 24 hours after injection and their number increases again after two weeks, which may play a role in the early clinical effect of intravitreal bevacizumab for macular edema.

TL;DR: In this paper, a combination of clinical examination (looking for new hemorrhage) and qualitative OCT (to assess response to treatment and early signs of recurrent leakage) can be used to guide anti-vascular endothelial growth factor (anti-VEGF), treatments with the goal of maintaining a "normal" retinal anatomy in an attempt to maximize the benefit (visual acuity gains) to risk (number of injections required) ratio.

TL;DR: The recent identification of bone-marrow derived stem cells in the corneal stroma suggests a further complexity in the regulation of the keratocyte phenotype following injury.

TL;DR: Data suggest that the main parameter for good visual function after DALK for keratoconus is the thickness of residual recipient stromal bed, which is similar to that of a PK.

TL;DR: Higher levels of weight gain and BMI are associated with greater risk of idiopathic intracranial hypertension and vision-specific and overall HRQOL are affected to a greater extent in IIH than in other neuro-ophthalmologic disorders.

TL;DR: In this article, the authors investigate Acanthamoeba keratitis (AK) risk factors, such as lens hygiene, contact lens solution use, and water exposure, using a case-control study at the University of Illinois at Chicago (UIC) Cornea Service.

TL;DR: HRQOL is diminished even in persons with relatively mild VFL on the basis of MD scores, and prevention and management of persons with VFL may be important in preventing or reducing poor HRQOL related to difficulties in driving, distance and peripheral vision activities, and a sense of dependency.

TL;DR: In this paper, the authors estimate the incidences of ocular complications and vision loss in patients with juvenile idiopathic arthritis (JIA)-associated uveitis, to describe risk factors for vision loss, and to describe the association between therapy and complications and visual loss.

TL;DR: Intravitreal injection of bevacizumab appears to result in significant short-term improvement of visual acuity and macular edema secondary to vein occlusion, which confirms the previous studies.