N
Nicholas R. English
Researcher at Imperial College London
Publications - 27
Citations - 2684
Nicholas R. English is an academic researcher from Imperial College London. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 19, co-authored 27 publications receiving 2549 citations.
Papers
More filters
Journal ArticleDOI
Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer.
Bond Almand,Joseph I. Clark,Ekaterina Yu. Nikitina,James van Beynen,Nicholas R. English,Stella C. Knight,David P. Carbone,Dmitry I. Gabrilovich +7 more
TL;DR: In this paper, the authors investigated the nature and functional role of immature macrophages and dendritic cells (ImC) in cancer patients and determined that the population of ImC is composed of a small percentage (<2%) of hemopoietic progenitor cells.
Journal ArticleDOI
Human peripheral blood contains two distinct lineages of dendritic cells.
Stephen Robinson,Steven Patterson,Nicholas R. English,Derek Davies,Stella C. Knight,C. D. L. Reid +5 more
TL;DR: The data suggest that these two populations of DC represent distinct lineages of antigen‐presenting DC, and that only the CD11c+ DC were able to take up antigen.
Journal ArticleDOI
Migration and Maturation of Human Colonic Dendritic Cells
Sally Bell,Rachael Rigby,Nicholas R. English,Steven D. Mann,Stella C. Knight,Michael A. Kamm,Andrew J. Stagg +6 more
TL;DR: The first analysis of the phenotype, maturational status, and migratory activity of human gut DC is presented in cells obtained by rapid collagenase digestion of human colonic and rectal biopsies.
Journal ArticleDOI
Murine dendritic cells internalize Leishmania major promastigotes, produce IL‐12 p40 and stimulate primary T cell proliferation in vitro
Pamela Konecny,Andrew J. Stagg,Heather Jebbari,Nicholas R. English,Robert N. Davidson,Stella C. Knight +5 more
TL;DR: DC are able to internalize metacyclic Leishmania promastigotes and that the fate of the parasites within DC differs from that within macrophages, suggesting that DC exposed to PM may be useful in immunotherapy and vaccination.
Journal ArticleDOI
Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum
Elizabeth R. Mann,David Bernardo,Nicholas R. English,J. Landy,Hafid O. Al-Hassi,Simon T. Peake,Ripple Man,T Elliott,Henning Spranger,Gui Han Lee,Alyssa Parian,Steven R. Brant,Mark Lazarev,Ailsa Hart,Xuhang Li,Stella C. Knight +15 more
TL;DR: The colon and the ileum should be regarded as separate entities, each comprising DC with distinct roles in mucosal immunity and imprinting, and the regulatory properties of colonic DC may represent an evolutionary adaptation to the greater bacterial load in the colon.