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Nicholas van Bruggen
Researcher at Genentech
Publications - 46
Citations - 7317
Nicholas van Bruggen is an academic researcher from Genentech. The author has contributed to research in topics: Vascular endothelial growth factor & Angiogenesis. The author has an hindex of 26, co-authored 44 publications receiving 6683 citations. Previous affiliations of Nicholas van Bruggen include Hoffmann-La Roche.
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Journal ArticleDOI
Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover
John Street,Min Bao,Leo Deguzman,Stuart Bunting,Franklin Peale,Napoleone Ferrara,Hope Steinmetz,John Hoeffel,Jeffrey L. Cleland,Ann L. Daugherty,Nicholas van Bruggen,H. Paul Redmond,Richard A.D. Carano,Ellen Filvaroff +13 more
TL;DR: The responses to exogenous VEGF observed in two distinct model systems and species indicate that a slow-release formulation of V EGF, applied locally at the site of bone damage, may prove to be an effective therapy to promote human bone repair.
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VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
Zheng Gang Zhang,Li Zhang,Quan Jiang,Ruilan Zhang,Kenneth Davies,Cecylia Powers,Nicholas van Bruggen,Michael Chopp +7 more
TL;DR: VEGF can markedly enhance angiogenesis in the ischemic brain and reduce neurological deficits during stroke recovery and that inhibition of VEGF at the acute stage of stroke may reduce the BBB permeability and the risk of hemorrhagic transformation after focal cerebral ischemia.
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Molecular imaging in drug development
TL;DR: The applications of molecular Imaging in drug development are reviewed, highlighting successes and identifying key challenges that need to be addressed for successful integration of molecular imaging into the drug development process.
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Bv8 regulates myeloid-cell-dependent tumour angiogenesis
Farbod Shojaei,Xiumin Wu,Cuiling Zhong,Lanlan Yu,Xiao-Huan Liang,Jenny Yao,Dominique Blanchard,Carlos Bais,Franklin Peale,Nicholas van Bruggen,Calvin Ho,Jed Ross,Martha Tan,Richard A.D. Carano,Y. Gloria Meng,Napoleone Ferrara +15 more
TL;DR: Bv8 modulates mobilization of CD11b+Gr1+ cells from the bone marrow during tumour development and also promotes angiogenesis locally, which is additive to those of anti-Vegf antibodies or cytotoxic chemotherapy.
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Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
Marcin Kowanetz,Xiumin Wu,John G. Lee,Martha Tan,Thijs J. Hagenbeek,Xueping Qu,Lanlan Yu,Jed Ross,Nina Korsisaari,Tim C. Cao,Hani Bou-Reslan,Dara Y. Kallop,Robby M. Weimer,Mary J. C. Ludlam,Joshua S. Kaminker,Zora Modrusan,Nicholas van Bruggen,Franklin Peale,Richard A.D. Carano,Y. Gloria Meng,Napoleone Ferrara +20 more
TL;DR: This study shows that metastatic tumors examined overexpress granulocyte-colony stimulating factor (G-CSF), which expands and mobilizes Ly6G+Ly6C+ granulocytes and facilitates their subsequent homing at distant organs even before the arrival of tumor cells.