T
Thijs J. Hagenbeek
Researcher at Genentech
Publications - 18
Citations - 2418
Thijs J. Hagenbeek is an academic researcher from Genentech. The author has contributed to research in topics: T cell & Hippo signaling pathway. The author has an hindex of 13, co-authored 17 publications receiving 2130 citations. Previous affiliations of Thijs J. Hagenbeek include Netherlands Cancer Institute.
Papers
More filters
Journal ArticleDOI
Therapeutic antibody targeting of individual Notch receptors
Yan Wu,Carol Cain-Hom,Lisa Choy,Thijs J. Hagenbeek,Gladys P. de Leon,Yongmei Chen,David Finkle,Rayna Venook,Xiumin Wu,John B. Ridgway,Dorreyah Schahin-Reed,Graham J. Dow,Amy L. Shelton,Scott Stawicki,Ryan J. Watts,Jeff Zhang,Robert Choy,Peter Howard,Lisa C. Kadyk,Minhong Yan,Jiping Zha,Christopher A. Callahan,Sarah G. Hymowitz,Christian W. Siebel +23 more
TL;DR: The studies emphasize the value of paralogue-specific antagonists in dissecting the contributions of distinct Notch receptors to differentiation and disease and reveal the therapeutic promise in targeting Notch1 and Notch2 independently.
Journal ArticleDOI
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
Marcin Kowanetz,Xiumin Wu,John G. Lee,Martha Tan,Thijs J. Hagenbeek,Xueping Qu,Lanlan Yu,Jed Ross,Nina Korsisaari,Tim C. Cao,Hani Bou-Reslan,Dara Y. Kallop,Robby M. Weimer,Mary J. C. Ludlam,Joshua S. Kaminker,Zora Modrusan,Nicholas van Bruggen,Franklin Peale,Richard A.D. Carano,Y. Gloria Meng,Napoleone Ferrara +20 more
TL;DR: This study shows that metastatic tumors examined overexpress granulocyte-colony stimulating factor (G-CSF), which expands and mobilizes Ly6G+Ly6C+ granulocytes and facilitates their subsequent homing at distant organs even before the arrival of tumor cells.
Journal ArticleDOI
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.
Linda V. Sinclair,David K. Finlay,Carmen Feijoo,Georgina H. Cornish,Alexander Gray,Ann Ager,Klaus Okkenhaug,Thijs J. Hagenbeek,Hergen Spits,Hergen Spits,Doreen A. Cantrell +10 more
TL;DR: PI(3)K-mTOR nutrient-sensing pathways also determined expression of the chemokine receptor CCR7 and regulated lymphocyte trafficking in vivo, showing that lymphocytes use PI( 3)K and mTOR to match metabolism and trafficking.
Journal ArticleDOI
PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth
Carlos Bais,Xiumin Wu,Jenny Yao,Suya Yang,Yongping Crawford,Mccutcheon Krista,Christine Tan,Ganesh Kolumam,Jean-Michel Vernes,Jeffrey Eastham-Anderson,Peter Haughney,Marcin Kowanetz,Thijs J. Hagenbeek,Ian Kasman,Hani Bou Reslan,Jed Ross,Nick van Bruggen,Richard A.D. Carano,Yu-Ju Gloria Meng,Jo-Anne Hongo,Jean Philippe Stephan,Masabumi Shibuya,Masabumi Shibuya,Napoleone Ferrara +23 more
TL;DR: Although anti-PlGF treatment inhibited wound healing, extravasation of B16F10 cells, and growth of a tumor engineered to overexpress the PlGF receptor (VEGFR-1), neutralization of PlGF using four novel blocking antibodies had no significant effect on tumor angiogenesis in 15 models.
Journal ArticleDOI
The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling
Thijs J. Hagenbeek,Marianne Naspetti,Fabrice Malergue,Fabien Garçon,Jacques A. Nunès,Kitty B.J.M. Cleutjens,Jan Trapman,Paul Krimpenfort,Hergen Spits,Hergen Spits +9 more
TL;DR: Data indicate that PTEN is an important regulator of proliferation of developing T cells in the thymus, and can substitute for both IL-7 and pre-TCR signals.