Dara Y. Kallop

TL;DR: This article showed that although ligand-dependent activation of the hedgehog signalling pathway has been associated with tumorigenesis in a number of human tissues, Hh ligands failed to activate signalling in tumour epithelial cells.

TL;DR: This study shows that metastatic tumors examined overexpress granulocyte-colony stimulating factor (G-CSF), which expands and mobilizes Ly6G+Ly6C+ granulocytes and facilitates their subsequent homing at distant organs even before the arrival of tumor cells.

TL;DR: Anti-Axl mAb can enhance the therapeutic efficacy of anti-VEGF, EGFR small-molecule inhibitors as well as chemotherapy.

TL;DR: In vitro, it is shown that genetic deletion of Caspase-3 is fully protective against sensory axon degeneration initiated by trophic factor withdrawal, but not injury-induced Wallerian degeneration, and a biochemical cascade from prosurvival Bcl2 family regulators to Caspasase-9, then Caspases-3, and then Cazase-6 is defined.

TL;DR: The discovery of CD98hc as a robust receptor-mediated transcytosis pathway for antibody delivery to the brain expands the current approaches available for enhancing brain uptake of therapeutic antibodies.