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Nick Tschernia
Researcher at University of Nevada, Reno
Publications - 10
Citations - 2425
Nick Tschernia is an academic researcher from University of Nevada, Reno. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications receiving 1979 citations.
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Journal ArticleDOI
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
Daniel W. Lee,James N. Kochenderfer,Maryalice Stetler-Stevenson,Yongzhi K Cui,Cindy Delbrook,Steven A. Feldman,Terry J. Fry,Rimas J. Orentas,Marianna Sabatino,Nirali N. Shah,Seth M. Steinberg,Dave Stroncek,Nick Tschernia,Constance M. Yuan,Hua Zhang,Ling Zhang,Steven A. Rosenberg,Alan S. Wayne,Crystal L. Mackall +18 more
TL;DR: CD19-CAR T cell therapy is feasible, safe, and mediates potent anti-leukaemic activity in children and young adults with chemotherapy-resistant B-precursor acute lymphoblastic leukaemia and non-Hodgkin lymphoma.
Journal ArticleDOI
Characterization of naturally-occurring humoral immunity to AAV in sheep.
Joseph Tellez,Kim Van Vliet,Yu-Shan Tseng,Jonathan D. Finn,Nick Tschernia,Graça Almeida-Porada,Valder R. Arruda,Mavis Agbandje-McKenna,Christopher D. Porada +8 more
TL;DR: It is suggested that sheep harbor endogenous AAV, which induces immunity to both intact capsid and to capsid epitopes presented following proteolysis during the course of infection.
Journal ArticleDOI
Tumor in the Crossfire: Inhibiting TGF-β to Enhance Cancer Immunotherapy
Nick Tschernia,James L. Gulley +1 more
TL;DR: In this article , the authors present a review of small-molecule inhibitors and immune checkpoint inhibitors targeting the TGF-β target in combination with the immunosuppressive tumor microenvironment.
Journal ArticleDOI
CAR T cells reach clinical milestone in prostate cancer
Journal ArticleDOI
A Phase I Single-Arm Study of Biweekly NHS-IL12 in Patients With Metastatic Solid Tumors.
Margaret E. Gatti-Mays,Nick Tschernia,Julius Strauss,Ravi A. Madan,Fatima Karzai,M. Bilusic,Jason M. Redman,Houssein Abdul Sater,Charalampos S. Floudas,Nicole Toney,Renee N. Donahue,Caroline Jochems,Jennifer L. Marte,Deneise C Francis,Sheri McMahon,Elizabeth Lamping,Lisa M. Cordes,Jeffrey Schlom,James L. Gulley +18 more
TL;DR: In this article , a single-arm, phase I trial evaluated NHS-IL12 12 µg/kg SC q2w or 16.8µg/ kg SC q 2w in patients with metastatic solid tumors.