G
Graça Almeida-Porada
Researcher at Wake Forest Institute for Regenerative Medicine
Publications - 158
Citations - 8750
Graça Almeida-Porada is an academic researcher from Wake Forest Institute for Regenerative Medicine. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 40, co-authored 149 publications receiving 8090 citations. Previous affiliations of Graça Almeida-Porada include Wake Forest University & University of Minnesota.
Papers
More filters
Journal ArticleDOI
AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells
Amy Yin,Sheri Miraglia,Esmail D. Zanjani,Graça Almeida-Porada,Makio Ogawa,Anne G. Leary,Johanna Olweus,John F. Kearney,David William Buck +8 more
TL;DR: AC133-selected cells engraft successfully in a fetal sheep transplantation model, and human cells harvested from chimeric fetal sheep bone marrow have been shown to successfully engraft secondary recipients, providing evidence for the long-term repopulating potential of AC133(+) cells.
Journal ArticleDOI
A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential
Gesine Kögler,Sandra Sensken,Judith A. Airey,Thorsten Trapp,Markus Müschen,Niklas Feldhahn,Stefanie Liedtke,Rüdiger V. Sorg,Johannes C. Fischer,Claudia Rosenbaum,Susanne Greschat,Andreas Knipper,Jörg Bender,Özer Degistirici,Jizong Gao,Arnold I. Caplan,Evan Colletti,Graça Almeida-Porada,Hans Werner Müller,Esmail D. Zanjani,Peter Wernet +20 more
TL;DR: A new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described, which grows adherently and can be expanded to 1015 cells without losing pluripotency.
Journal Article
Human bone marrow CD34- cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells.
TL;DR: It is demonstrated that the CD34- fraction of normal human bone marrow contains cells capable of engraftment and differentiation into CD34+ progenitors and multiple lymphohematopoietic lineages in primary and secondary hosts.
Journal ArticleDOI
Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning.
Joana R. Ferreira,Graciosa Q. Teixeira,Susana G. Santos,Mário A. Barbosa,Graça Almeida-Porada,Raquel Gonçalves +5 more
TL;DR: This manuscript reviews the existent literature on how preconditioning of MSCs affects the therapeutic potential of their secretome, focusing on MSC's immunomodulatory and regenerative features, thereby providing new insights for the therapeutic use of M SCs' secretome.
Journal ArticleDOI
Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation.
TL;DR: The cotransplantation of both autologous and allogeneic human bone marrow-derived stromal cell progenitors resulted in an enhancement of long-term engraftment of human cells in the bone marrow of the chimeric animals and in earlier and higher levels of donor cells in circulation both during gestation and after birth.