N
Nickolas A. Lavidis
Researcher at University of Queensland
Publications - 60
Citations - 1371
Nickolas A. Lavidis is an academic researcher from University of Queensland. The author has contributed to research in topics: Neurotransmission & Oxidative stress. The author has an hindex of 19, co-authored 59 publications receiving 1131 citations.
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Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress
TL;DR: The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucoc Corticoid exposure.
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Dynamin Inhibition Blocks Botulinum Neurotoxin Type A Endocytosis in Neurons and Delays Botulism
Callista B. Harper,Sally Martin,Tam H. Nguyen,Shari J. Daniels,Nickolas A. Lavidis,Michel R. Popoff,Gordana Hadzic,Anna Mariana,Ngoc Chau,Adam McCluskey,Phillip J. Robinson,Frederic A. Meunier +11 more
TL;DR: It is found that inhibiting dynamin with the novel potent Dynasore analog, Dyngo-4aTM, was sufficient to abolish BoNT/A-Hc internalization and BoNT-induced SNAP25 cleavage in hippocampal neurons and provides a therapeutic avenue for the treatment of botulism and other diseases caused by pathogens sharing dynamin-dependent uptake mechanisms.
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Low dose prenatal ethanol exposure induces anxiety-like behaviour and alters dendritic morphology in the basolateral amygdala of rat offspring.
TL;DR: This study is the first to link increases in anxiety like behaviour to structural changes within the basolateral amygdala in a model of prenatal ethanol exposure and has shown that exposure to even a relatively small amount of alcohol during development leads to long term alterations in anxiety-like behaviour.
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Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
TL;DR: The results from the SOD1 model suggest that dendrite and dendritic spine changes foreshadow and underpin the neuromotor phenotypes present in ALS and may contribute to the varied cognitive, executive function and extra-motor symptoms commonly seen in ALS patients.
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The toxicological effects of petroleum spray oils on insects – Evidence for an alternative mode of action and possible new control options
TL;DR: It is demonstrated conclusively that at least some modern PSOs do not kill insects by anoxia, but by a range of cellular disruptions that lead to rapid insect death.