N
Nico Pfeifer
Researcher at University of Tübingen
Publications - 96
Citations - 4825
Nico Pfeifer is an academic researcher from University of Tübingen. The author has contributed to research in topics: Computer science & Antibody. The author has an hindex of 27, co-authored 84 publications receiving 3772 citations. Previous affiliations of Nico Pfeifer include Max Planck Society & Microsoft.
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Posted ContentDOI
Unique and assay specific features of NOMe-, ATAC- and DNase I-seq data
Karl Nordström,Florian Schmidt,Florian Schmidt,Nina Gasparoni,Abdulrahman Salhab,Gilles Gasparoni,Kathrin Kattler,Fabian Müller,Peter Ebert,Ivan G. Costa,Nico Pfeifer,Thomas Lengauer,Marcel H. Schulz,Marcel H. Schulz,Jörn Walter +14 more
TL;DR: This comparison strongly suggest to consider assay specific differences for the experimental desgin and for generalized and comparative functional interpretations of the genome.
Journal ArticleDOI
Modeling the Amplification of Immunoglobulins through Machine Learning on Sequence-Specific Features.
TL;DR: A novel Taq PCR data set is generated that reports the amplification status for pairs of primers and templates from a reference set of 47 immunoglobulin heavy chain variable sequences and 20 primers using TMM, a model for predicting whether a primer amplifies a template given their nucleotide sequences.
Proceedings ArticleDOI
XplOit: An Ontology-Based Data Integration Platform Supporting the Development of Predictive Models for Personalized Medicine.
Gabriele Weiler,Ulf Schwarz,Jochen Rauch,Kerstin Rohm,Thorsten Lehr,Stefan Theobald,Stephan Kiefer,Katharina Götz,Katharina Och,Nico Pfeifer,Lisa Handl,Sigrun Smola,Matthias Ihle,Amin T. Turki,Dietrich W. Beelen,Jürgen Rissland,Jörg Thomas Bittenbring,Norbert Graf +17 more
TL;DR: An ontology-based platform that supports data owners and model developers to share and harmonize their data for model development respecting data privacy is presented, driven by the demand for predictive instruments in allogeneic stem cell transplantation.
Journal ArticleDOI
Primarily oseltamivir-resistant influenza A (H1N1pdm09) virus evolving into a multidrug-resistant virus carrying H275Y and I223R neuraminidase substitutions.
Sebastian Grund,Charikleia Gkioule,Tahani Termos,Nico Pfeifer,Guido Kobbe,Jens Verheyen,Ortwin Adams +6 more
TL;DR: A patient who was infected with a primarily oseltamivir-resistant influenza A (H1N1pdm09) virus following allogeneic stem cell transplantation and rituximab treatment survived the influenza infection after 170 days of follow-up and the neuraminidase amino acid substitutions H275Y and I223R were detected.
Posted ContentDOI
openPrimeR for multiplex amplification of highly diverse templates
Christoph Kreer,Matthias Döring,Nathalie Lehnen,Meryem S. Ercanoglu,Lutz Gieselmann,Domnica Luca,Kanika Jain,Philipp Schommers,Nico Pfeifer,Florian Klein +9 more
TL;DR: OpenPrimeR, an R-based tool for evaluating and designing multiplex PCR primers, provides a functional and intuitive interface and uses either a greedy algorithm or an integer linear program to compute the minimal set of primers that performs full target coverage.