N
Nico Pfeifer
Researcher at University of Tübingen
Publications - 96
Citations - 4825
Nico Pfeifer is an academic researcher from University of Tübingen. The author has contributed to research in topics: Computer science & Antibody. The author has an hindex of 27, co-authored 84 publications receiving 3772 citations. Previous affiliations of Nico Pfeifer include Max Planck Society & Microsoft.
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Journal ArticleDOI
TOPP---the OpenMS proteomics pipeline
Oliver Kohlbacher,Knut Reinert,Clemens Gröpl,Eva Lange,Nico Pfeifer,Ole Schulz-Trieglaff,Marc Sturm +6 more
TL;DR: The basic concepts and the current abilities of TOPP are described and illustrated in the context of two example applications: the identification of peptides from a raw dataset through database search and the complex analysis of a standard addition experiment for the absolute quantitation of biomarkers.
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HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1
Till Schoofs,Florian Klein,Florian Klein,Florian Klein,Malte Braunschweig,Malte Braunschweig,Edward F. Kreider,Anna Feldmann,Lilian Nogueira,Thiago Y. Oliveira,Julio C. C. Lorenzi,Erica H. Parrish,Gerald H. Learn,Anthony P. West,Pamela J. Bjorkman,Sarah J. Schlesinger,Michael S. Seaman,Julie Czartoski,M. Juliana McElrath,Nico Pfeifer,Beatrice H. Hahn,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +23 more
TL;DR: HIV-1 immunotherapy with a single injection of 3BNC117 affects host antibody responses in viremic individuals and enhances host humoral immunity to HIV-1, and neutralizing antibodies may be a promising therapy for HIV- 1 because of their potential to reduce the viral reservoir.
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Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.
Yotam Bar-On,Henning Gruell,Till Schoofs,Joy A. Pai,Lilian Nogueira,Allison L. Butler,Katrina G. Millard,Clara Lehmann,Isabelle Suárez,Thiago Y. Oliveira,Theodora K. Karagounis,Yehuda Z. Cohen,Christoph Wyen,Christoph Wyen,Stefan Scholten,Lisa Handl,Shiraz A. Belblidia,Juan Dizon,Jörg Janne Vehreschild,Maggi Witmer-Pack,Irina Shimeliovich,Kanika Jain,Kerstin Fiddike,Kelly E. Seaton,Nicole L. Yates,Jill Horowitz,Roy M. Gulick,Nico Pfeifer,Georgia D. Tomaras,Michael S. Seaman,Gerd Fätkenheuer,Marina Caskey,Florian Klein,Michel C. Nussenzweig,Michel C. Nussenzweig +34 more
TL;DR: Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.
Journal ArticleDOI
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
Istvan Bartha,Jonathan M. Carlson,Chanson J. Brumme,Paul J. McLaren,Paul J. McLaren,Paul J. McLaren,Zabrina L. Brumme,Mina John,David W. Haas,Javier Martinez-Picado,Javier Martinez-Picado,Judith Dalmau,Cecilio López-Galíndez,Concepción Casado,Andri Rauch,Huldrych F. Günthard,Enos Bernasconi,Pietro Vernazza,Thomas Klimkait,Sabine Yerly,Stephen J. O'Brien,Jennifer Listgarten,Nico Pfeifer,Christoph Lippert,Nicolo Fusi,Zoltán Kutalik,Zoltán Kutalik,Todd M. Allen,Viktor Müller,P. Richard Harrigan,David Heckerman,Amalio Telenti,Jacques Fellay,Jacques Fellay,Jacques Fellay +34 more
TL;DR: Two critical advantages to the use of viral variation for identifying host factors are identified: (1) association signals are much stronger for HIV-1 sequence variants than VL, reflecting the ‘intermediate phenotype’ nature of viral variations; (2) association testing can be run without any clinical data.
Journal ArticleDOI
Integrating different data types by regularized unsupervised multiple kernel learning with application to cancer subtype discovery.
Nora K. Speicher,Nico Pfeifer +1 more
TL;DR: Current multiple kernel learning for dimensionality reduction approaches are applied and extended, and it is shown that one can even use several kernels per data type and thereby alleviate the user from having to choose the best kernel functions and kernel parameters for each data type beforehand.