N
Nicola Angel
Researcher at University of Queensland
Publications - 16
Citations - 2312
Nicola Angel is an academic researcher from University of Queensland. The author has contributed to research in topics: Tartrate-resistant acid phosphatase & Messenger RNA. The author has an hindex of 10, co-authored 16 publications receiving 1570 citations.
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Journal ArticleDOI
First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: A proof of concept for the wastewater surveillance of COVID-19 in the community.
Warish Ahmed,Nicola Angel,Janette Edson,Kyle Bibby,Aaron Bivins,Jake W. O'Brien,Phil M. Choi,Masaaki Kitajima,Stuart L. Simpson,Jiaying Li,Benjamin J. Tscharke,Rory Verhagen,Wendy Smith,Julian Zaugg,Leanne Dierens,Philip Hugenholtz,Kevin V. Thomas,Jochen F. Mueller +17 more
TL;DR: The quantification of SARS-CoV-2 in wastewater affords the ability to monitor the prevalence of infections among the population via wastewater-based epidemiology (WBE) and highlights the viability of WBE for monitoring infectious diseases, such as COVID-19, in communities.
Journal ArticleDOI
Structure, function, and regulation of tartrate-resistant acid phosphatase.
G.W. Oddie,Gerhard Schenk,Nicola Angel,N. Walsh,Luke W. Guddat,J. de Jersey,A. I. Cassady,Susan E. Hamilton,David A. Hume +8 more
TL;DR: The view that TRAP, like several other hydrolases, is synthesized as a relatively inactive proen enzyme, and cleavage is the physiological mechanism of proenzyme activation in osteoclasts is put forth.
Journal ArticleDOI
Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover.
TL;DR: Measurements of the bone formation rate suggest that the animals compensate for the increased resorption by increasing bone synthesis, which partly ameliorates the phenotype, and provides evidence that inclusion of an irrelevant enhancer does not necessarily override a tissue‐specific promoter.
Journal ArticleDOI
Detection of SARS-CoV-2 RNA in commercial passenger aircraft and cruise ship wastewater: a surveillance tool for assessing the presence of COVID-19 infected travellers.
Warish Ahmed,Paul M. Bertsch,Nicola Angel,Kyle Bibby,Aaron Bivins,Leanne Dierens,Janette Edson,John Ehret,Pradip Gyawali,Kerry A. Hamilton,Ian Hosegood,Philip Hugenholtz,Guangming Jiang,Masaaki Kitajima,Homa Teimouri Sichani,Jiahua Shi,Katja M. Shimko,Stuart L. Simpson,Wendy Smith,Erin M. Symonds,Kevin V. Thomas,Rory Verhagen,Julian Zaugg,Jochen F. Mueller +23 more
TL;DR: Surveillance of wastewater from large transport vessels with their own sanitation systems has potential as a complementary data source to prioritize clinical testing and contact tracing among disembarking passengers and must be further optimized to maximize detection sensitivity.
Journal ArticleDOI
The Microphthalmia Transcription Factor Regulates Expression of the Tartrate‐Resistant Acid Phosphatase Gene During Terminal Differentiation of Osteoclasts
A Luchin,Georgia Ellen Purdom,Kathleen M. Murphy,MY Clark,Nicola Angel,A. I. Cassady,David A. Hume,Michael C. Ostrowski +7 more
TL;DR: Several lines of evidence show that the gene encoding the enzyme tartrate‐resistant acid phosphatase (TRAP) is a target of microphthalmia transcription factor (MITF) and will allow osteoclast‐specific mechanisms of gene regulation to be studied in greater detail.