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Nicola Angel

Researcher at University of Queensland

Publications -  16
Citations -  2312

Nicola Angel is an academic researcher from University of Queensland. The author has contributed to research in topics: Tartrate-resistant acid phosphatase & Messenger RNA. The author has an hindex of 10, co-authored 16 publications receiving 1570 citations.

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Journal ArticleDOI

Structure, function, and regulation of tartrate-resistant acid phosphatase.

TL;DR: The view that TRAP, like several other hydrolases, is synthesized as a relatively inactive proen enzyme, and cleavage is the physiological mechanism of proenzyme activation in osteoclasts is put forth.
Journal ArticleDOI

Transgenic mice overexpressing tartrate-resistant acid phosphatase exhibit an increased rate of bone turnover.

TL;DR: Measurements of the bone formation rate suggest that the animals compensate for the increased resorption by increasing bone synthesis, which partly ameliorates the phenotype, and provides evidence that inclusion of an irrelevant enhancer does not necessarily override a tissue‐specific promoter.
Journal ArticleDOI

The Microphthalmia Transcription Factor Regulates Expression of the Tartrate‐Resistant Acid Phosphatase Gene During Terminal Differentiation of Osteoclasts

TL;DR: Several lines of evidence show that the gene encoding the enzyme tartrate‐resistant acid phosphatase (TRAP) is a target of microphthalmia transcription factor (MITF) and will allow osteoclast‐specific mechanisms of gene regulation to be studied in greater detail.