Nicola Boulter

TL;DR: Analysis of the cytotoxic T-cell response has revealed evidence of BoLA haplotype dominance plus competition between parasite epitopes, but further vaccine development will probably require identification of a range of other antigens, especially from the schizont stage.

TL;DR: SPAG‐1, a sporozoite surface antigen of T. annulata, has previously been shown to elicit partial protection when used, as an hepatitis B core antigen fusion, to immunize cattle, and this study was to try and improve the protective capacity of this antigen by enlisting different vaccine strategies.

TL;DR: The combination of SPAG-1 and the attenuated cell line induced the best protection as indicated by the survival of all the vaccinated calves, demonstrating the enhanced protection provided by combining sporozoite and schizont antigens in vaccination against tropical theileriosis.

TL;DR: P67 and SPAG-1 were found to contain cross-reactive determinants responsible for neutralization of sporozoite infectivity in vitro, and at least some of these were located in the C-termini of both molecules.

TL;DR: The data point to the conclusion that SPAG‐1 can elicit partial protection and is therefore suitable for inclusion in an eventual multicomponent subunit vaccine.