N
Nicola Origlia
Researcher at National Research Council
Publications - 56
Citations - 2100
Nicola Origlia is an academic researcher from National Research Council. The author has contributed to research in topics: Long-term potentiation & Entorhinal cortex. The author has an hindex of 23, co-authored 50 publications receiving 1728 citations. Previous affiliations of Nicola Origlia include University of Pisa.
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Journal ArticleDOI
Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid-β-Mediated Cortical Synaptic Dysfunction
Nicola Origlia,Massimo Righi,Simona Capsoni,Antonino Cattaneo,Fang Fang,David M. Stern,John Xi Chen,Ann Marie Schmidt,Ottavio Arancio,Shirley ShiDu Yan,Luciano Domenici +10 more
TL;DR: The results indicate that Aβ impairs LTP in the entorhinal cortex through neuronal RAGE-mediated activation of p38 MAPK.
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Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder.
Liliana Dell'Osso,Claudia Carmassi,Alessandro Del Debbio,Mario Catena Dell'Osso,Carolina Bianchi,Eleonora Da Pozzo,Nicola Origlia,Luciano Domenici,Luciano Domenici,Gabriele Massimetti,Donatella Marazziti,Armando Piccinni +11 more
TL;DR: The results, while showing significantly lower BDNF levels in PTSD patients, as compared with those of healthy subjects, would suggest that this NT may be involved in the pathophysiology of PTSD.
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Plasma Brain-Derived Neurotrophic Factor in treatment-resistant depressed patients receiving electroconvulsive therapy
Armando Piccinni,Alessandro Del Debbio,Pierpaolo Medda,Carolina Bianchi,Isabella Roncaglia,Antonello Veltri,S. Zanello,Enrico Massimetti,Nicola Origlia,Luciano Domenici,Luciano Domenici,Donatella Marazziti,Liliana Dell'Osso +12 more
TL;DR: The findings would suggest the potential usefulness of baseline plasma BDNF levels as predictors of response to ECT in treatment-resistant depressed patients.
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Diurnal variation of plasma brain-derived neurotrophic factor (BDNF) in humans: an analysis of sex differences.
Armando Piccinni,Donatella Marazziti,Alessandro Del Debbio,Carolina Bianchi,Isabella Roncaglia,Claudio Mannari,Nicola Origlia,Mario Catena Dell'Osso,Gabriele Massimetti,Luciano Domenici,Liliana Dell'Osso +10 more
TL;DR: Findings support the concept of rhythmic variation in plasma BDNF regulation that seems to be sex‐related, and explore plasma and serum BDNF levels at three different clock times in a study of 28 healthy subjects of both sexes.
Journal ArticleDOI
Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives β-Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex
Nicola Origlia,Camilla Bonadonna,Alfredo Rosellini,Elena Leznik,Ottavio Arancio,Shirley ShiDu Yan,Luciano Domenici +6 more
TL;DR: Findings suggest a prominent role of microglial RAGE signaling in Aβ-induced EC synaptic dysfunction, and particularly in slices from mice expressing a defective form of RAGE targeted to microglia.