Nicolas Sabarth

TL;DR: A comprehensive secretome analysis that uses protein-free culture conditions to minimize autolysis, an efficient recovery method for extracellular proteins, and two-dimensional gel electrophoresis followed by peptide mass fingerprinting for protein resolution and identification is reported on.

TL;DR: This generally applicable combined proteome approach facilitates the rapid identification of promising targets for the control of H. pylori and might be applicable to numerous other human pathogens although larger biotinylation reagents might be required in some cases to prevent permeation of porin channels in the outer membrane.

TL;DR: Compared to a previous study intensified dosing and/or i.d. injections enhanced the response rates to the vaccine IC41 in three assays measuring T cell function, which justifies testing IC 41 in further clinical trials with HCV-infected individuals.

TL;DR: A series of immunogenicity and protection studies following active immunization of mice indicate that a whole virus, nonadjuvanted vaccine is immunogenic at low doses and protects against live virus challenge.

TL;DR: It is demonstrated the effective induction of NAi antibody titers after H5N1 vaccination in humans, and a single vaccine dose induced a strong NAi response that was not significantly boosted by a second dose, most probably due to priming by previous vaccination or infection with seasonal influenza viruses.