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Nicolas Simon
Researcher at Aix-Marseille University
Publications - 165
Citations - 3097
Nicolas Simon is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 31, co-authored 158 publications receiving 2612 citations. Previous affiliations of Nicolas Simon include University of the Mediterranean.
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Journal ArticleDOI
Sodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
J. Guiraud,Giovanni Addolorato,Manila Antonelli,Henri-Jean Aubin,Andrea de Bejczy,Amine Benyamina,Roberto Cacciaglia,Fabio Caputo,Maurice Dematteis,Anna Ferrulli,Anna E. Goudriaan,Antoni Gual,Otto M. Lesch,Icro Maremmani,Antonio Mirijello,David J. Nutt,François Paille,Pascal Perney,Roch Poulnais,Quentin Raffaillac,Jürgen Rehm,Benjamin Rolland,Claudia Rotondo,Bruno Scherrer,Nicolas Simon,Katrin Skala,Bo Söderpalm,Lorenzo Somaini,Wolfgang H. Sommer,Rainer Spanagel,Gabriele Angelo Vassallo,Henriette Walter,W. M. Van Den Brink +32 more
TL;DR: A large RCT in alcohol-dependent patients demonstrated a significant and clinically relevant sustained effect of SMO on CAD and the SMO effect was sustained during the medication-free follow-up period.
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Comorbidities and the right dose: antipsychotics
TL;DR: The pharmacokinetic profiles of seven oral antipsychotics are reviewed, focusing on renal and hepatic impairment, and factors liable to impact antipsychotic dosage are numerous and their subsequent effects often hard to predict, due to multilevel interactions and compensatory phenomena.
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An observational study of benzodiazepine prescription during inpatient alcohol detoxification for patients with versus without chronic pretreatment with high dosage baclofen.
TL;DR: The article by Martinez et al. provides some information on the management of patients with AUD under baclofen treatment and requiring alcohol detoxification and interestingly, they did not observe any significant difference between the doses of benzodiazepine required for their patients during detoxification.
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Intoxication par ingestion de Chlorophyllum molybdites sur l’Île de la Réunion : à propos d’un cas
TL;DR: Auteurs decrivent le cas d'un patient âge de 43, who a developpe un syndrome resinoidien une heure trente apres avoir mange 3 specimens of Chlorophyllum molybdites cuits, qu’il avait recoltes en ete dans le Sud Ouest de l’ile en pensant cueillir des volvaires.
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Population pharmacokinetics of methadone hydrochloride after a single intramuscular administration in adult Japanese sika deer (Cervus nippon nippon).
Christopher Scala,Amélie Marsot,Marie-Josée Limoges,Yann Locatelli,Nicolas Simon,Jean-Claude Alvarez +5 more
TL;DR: Following intramuscular injection, methadone was characterized by a large total volume of distribution, high systemic clearance and intermediate terminal half-life in sika deer, and a two-compartment linear disposition model best described observed time-concentration profiles.