R
Rainer Spanagel
Researcher at Heidelberg University
Publications - 411
Citations - 27255
Rainer Spanagel is an academic researcher from Heidelberg University. The author has contributed to research in topics: Addiction & Nucleus accumbens. The author has an hindex of 85, co-authored 385 publications receiving 24947 citations. Previous affiliations of Rainer Spanagel include Indiana University – Purdue University Indianapolis & Max Planck Society.
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Journal ArticleDOI
The dopamine hypothesis of reward: past and current status
Rainer Spanagel,Friedbert Weiss +1 more
TL;DR: Evidence suggests that dopaminergic-neuron activation aids the organism in learning to recognize stimuli associated with internal rewarding or aversive events and long-lasting neuroadaptive changes in mesolimbic dopamine-mediated transmission that develop during chronic drug use might contribute to compulsive drug-seeking behavior and relapse.
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Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway
TL;DR: Data show that tonic activation of mu and kappa receptors is required for the maintenance of basal dopamine release in the nucleus accumbens, which may have implications for the treatment of opiate dependence and affective disorders.
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Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
Peter Timpl,Rainer Spanagel,Inge Sillaber,Adelheid E. Kresse,Johannes M. H. M. Reul,Günter K. Stalla,Veronique Blanquet,Thomas Steckler,Florian Holsboer,Wolfgang Wurst +9 more
TL;DR: It is shown that in mice lacking Crhr1, the medulla of the adrenal gland is atrophied and stress-induced release of adrenocorticotropic hormone (ACTH) and corticosterone is reduced and the homozygous mutants exhibit increased exploratory activity and reduced anxiety-related behaviour under both basal conditions and following alcohol withdrawal.
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Alcoholism: a systems approach from molecular physiology to addictive behavior.
TL;DR: This review adheres to a systems biology perspective such that the interaction of alcohol with primary and secondary targets within the brain is described in relation to the behavioral consequences.
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Behavioural assessment of drug reinforcement and addictive features in rodents: an overview.
TL;DR: This review provides an extensive overview and a critical evaluation of the methods currently used for studying drug‐induced reinforcement as well as specific features of addictive behaviour, and various procedures have been proposed as possible rodent analogues of addiction’s major elements.