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Wolfgang H. Sommer
Researcher at Heidelberg University
Publications - 169
Citations - 7844
Wolfgang H. Sommer is an academic researcher from Heidelberg University. The author has contributed to research in topics: Alcohol dependence & Medicine. The author has an hindex of 48, co-authored 143 publications receiving 6921 citations. Previous affiliations of Wolfgang H. Sommer include Karolinska Institutet & National Institutes of Health.
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Journal ArticleDOI
Genome-wide association study of alcohol dependence.
Jens Treutlein,Sven Cichon,Monika Ridinger,Norbert Wodarz,Michael Soyka,Peter Zill,Wolfgang Maier,Rainald Moessner,Wolfgang Gaebel,Norbert Dahmen,Christoph Fehr,Norbert Scherbaum,Michael Steffens,Kerstin U. Ludwig,Josef Frank,H.-Erich Wichmann,Stefan Schreiber,Nico Dragano,Wolfgang H. Sommer,Fernando Leonardi-Essmann,Anbarasu Lourdusamy,Peter J. Gebicke-Haerter,Thomas F. Wienker,Patrick F. Sullivan,Markus M. Nöthen,Falk Kiefer,Rainer Spanagel,Karl Mann,Marcella Rietschel +28 more
TL;DR: This is the first GWAS and follow-up study to identify a genome-wide significant association in alcohol dependence and nine SNPs were located in genes that have been reported to be associated with alcohol dependence, including the CDH13 and ADH1C genes.
Journal ArticleDOI
Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
TL;DR: It is demonstrated that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long‐lasting increase in voluntary ethanol intake, which is likely to be encoded by long‐term changes in gene expression.
Journal ArticleDOI
Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence.
Wolfgang H. Sommer,Roberto Rimondini,Anita C. Hansson,Philip Arthur Hipskind,Donald R. Gehlert,Christina S. Barr,Markus Heilig +6 more
TL;DR: Alcohol drinking was upregulated long-term following a history of dependence and fear suppression of behavior was selectively potentiated in postdependent animals.
Journal ArticleDOI
A genetic determinant of the striatal dopamine response to alcohol in men
Vijay A. Ramchandani,John C. Umhau,Francisco Javier Pavón,Victor Ruiz-Velasco,Wojciech Margas,Hui Sun,Ruslan Damadzic,Robert L. Eskay,Michael Schoor,Annika Thorsell,Melanie L. Schwandt,Wolfgang H. Sommer,David T. George,Loren H. Parsons,Peter Herscovitch,Daniel W. Hommer,Markus Heilig +16 more
TL;DR: It is reported that a functional OPRM1 A118G polymorphism is a major determinant of striatal dopamine responses to alcohol, a mechanism by which it likely modulates alcohol reward.
Journal ArticleDOI
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Gunter Schumann,Lachlan J. M. Coin,Anbarasu Lourdusamy,Pimphen Charoen,Pimphen Charoen,Karen H. Berger,David Stacey,Sylvane Desrivières,Fazil Aliev,Anokhi Ali Khan,Najaf Amin,Yurii S. Aulchenko,Georgy Bakalkin,Stephan J. L. Bakker,Beverley Balkau,Beverley Balkau,Joline W.J. Beulens,Ainhoa Bilbao,Rudolf A. de Boer,Delphine Beury,Michiel L. Bots,Elemi J. Breetvelt,Stéphane Cauchi,Christine Cavalcanti-Proença,John C. Chambers,Toni-Kim Clarke,Norbert Dahmen,Eco J. C. de Geus,Danielle M. Dick,Francesca Ducci,Alanna C. Easton,Howard J. Edenberg,Tõnu Esko,Alberto Fernández-Medarde,Tatiana Foroud,Nelson B. Freimer,Jean-Antoine Girault,Diederick E. Grobbee,Simonetta Guarrera,Daniel F. Gudbjartsson,Anna-Liisa Hartikainen,Andrew C. Heath,Victor Hesselbrock,Albert Hofman,Jouke-Jan Hottenga,Matti Isohanni,Jaakko Kaprio,Kay-Tee Khaw,Brigitte Kuehnel,Jaana Laitinen,Stéphane Lobbens,Jian'an Luan,Massimo Mangino,Matthieu Maroteaux,Giuseppe Matullo,Mark I. McCarthy,Christian Mueller,Christian Mueller,Gerjan Navis,Mattijs E. Numans,Alejandro Núñez,Dale R. Nyholt,Charlotte Onland-Moret,Charlotte Onland-Moret,Ben A. Oostra,Paul F. O'Reilly,Miklós Palkovits,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Silvia Polidoro,Anneli Pouta,Inga Prokopenko,Fulvio Ricceri,Eugenio Santos,Johannes H. Smit,Nicole Soranzo,Nicole Soranzo,Kijoung Song,Ulla Sovio,Michael Stumvoll,Ida Surakk,Thorgeir E. Thorgeirsson,Unnur Thorsteinsdottir,Claire Troakes,Thorarinn Tyrfingsson,Anke Tönjes,Cuno S.P.M. Uiterwaal,André G. Uitterlinden,Pim van der Harst,Yvonne T. van der Schouw,Oliver Staehlin,Nicole Vogelzangs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,John Whitfield,Erich Wichmann,Gonneke Willemsen,Jacqueline C.M. Witteman,Xin Yuan,Guangju Zhai,Jing Hua Zhao,Weihua Zhang,Nicholas G. Martin,Andres Metspalu,Angela Doering,James Scott,Tim D. Spector,Ruth J. F. Loos,Dorret I. Boomsma,Vincent Mooser,Leena Peltonen,Leena Peltonen,Kari Stefansson,Cornelia M. van Duijn,Paolo Vineis,Wolfgang H. Sommer,Jaspal S. Kooner,Rainer Spanagel,Ulrike Heberlein,Marjo-Riitta Järvelin,Paul Elliott +122 more
TL;DR: A genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption among 12 population-based samples of European ancestry finds a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples and finds a regulator of alcohol consumption.