Nicolas Simon

TL;DR: Aripiprazole and cariprazine are efficacious and generally well tolerated agents that have shown cost effectiveness, and may therefore enrich the therapeutic armamentarium for bipolar illness.

TL;DR: In this article, the authors conducted a systematic literature review on placebo-controlled RCTs for alcohol dependence and found that the placebo response is lower in very heavy drinkers who show no "spontaneous improvement" prior to treatment initiation (high-severity population) than in a mild-versity population and in studies with longer treatment duration.

TL;DR: Simulations have allowed the authors to describe new dosage schedules, and a chart was created to help clinicians to adapt dosage of vancomycin, and showed that the maintenance dose should be adjusted more precisely to each neonate based on his or her weight and serum creatinine value.

TL;DR: There is now increasing evidence from both efficacy and effectiveness studies, that APP may be beneficial for some schizophrenia patients, and the most evidence seems to be for the combination of clozapine and aripiprazole.

TL;DR: The results showed that morning administration of caffeine suppressed the daily rhythmicity of LA and modified the mesors and amplitudes of the HR and BT daily rhythms, while the evening administration did not suppress thedaily rhythm of LA, but altered the mesor, amplitudes and acrophases of the three rhythms, indicating a chronopharmacological effect.