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Nicole D. Pecora
Researcher at University of Rochester Medical Center
Publications - 42
Citations - 1394
Nicole D. Pecora is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 12, co-authored 37 publications receiving 1182 citations. Previous affiliations of Nicole D. Pecora include University of Rochester & Harvard University.
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Journal ArticleDOI
The trans-envelope Tol-Pal complex is part of the cell division machinery and required for proper outer-membrane invagination during cell constriction in E. coli.
TL;DR: It is proposed that Tol–Pal constitutes a dynamic subcomplex of the division apparatus in Gram‐negative bacteria that consumes energy to establish transient trans‐envelope connections at/near the septal ring to draw the OM onto the invaginating PG and IM layers during constriction.
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Mycobacterium tuberculosis LprA Is a Lipoprotein Agonist of TLR2 That Regulates Innate Immunity and APC Function
TL;DR: Mtb LprA is a TLR2 agonist that induces cytokine responses and regulates APC function and may represent a negative feedback mechanism for control of inflammation that may be subverted by Mtb for immune evasion.
Journal ArticleDOI
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Michael G. Drage,Nicole D. Pecora,Amy G. Hise,Maria Febbraio,Roy L. Silverstein,Douglas T. Golenbock,W. Henry Boom,Clifford V. Harding +7 more
TL;DR: Lung APC subsets differ in TLR expression, which may determine differences in responses to Mtb, and lower TLR2 expression by CD11b(high)/CD11c(low) lung macrophages than CD11 b(low)/CD 11c(high) alveolar Macrophages, which correlated with hyporesponsiveness of lung macophages to LpqH.
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Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
Michael G. Drage,Han Chun Tsai,Nicole D. Pecora,Tan Yun Cheng,Ahmad R. Arida,Supriya Shukla,Roxana E. Rojas,Chetan Seshadri,D. Branch Moody,W. Henry Boom,James C. Sacchettini,Clifford V. Harding +11 more
TL;DR: A glycolipid binding function of LprG is demonstrated that enhances recognition of triacylated MTB glycolIPids by TLR2 and may affect gly colipid assembly or transport for bacterial cell wall biogenesis.
Journal ArticleDOI
Genomically Informed Surveillance for Carbapenem-Resistant Enterobacteriaceae in a Health Care System
Nicole D. Pecora,Ning Li,Marc W. Allard,Cong Li,Esperanza Albano,Mary L. Delaney,Andrea M. DuBois,Andrew B. Onderdonk,Lynn Bry +8 more
TL;DR: The utility of genomic analyses in internal and external surveillance efforts to stem the transmission of drug-resistant strains within and across health care institutions is highlighted and detection of resistance genes within mobile elements and resistance-carrying strains furthers active surveillance efforts for drug resistance.