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Nicole J. Darling
Researcher at University of California, Los Angeles
Publications - 10
Citations - 752
Nicole J. Darling is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Self-healing hydrogels & Click chemistry. The author has an hindex of 6, co-authored 8 publications receiving 406 citations. Previous affiliations of Nicole J. Darling include Duke University.
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Journal ArticleDOI
In situ forming injectable hydrogels for drug delivery and wound repair.
TL;DR: This review highlights injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair and provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body.
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Controlling the kinetics of thiol-maleimide Michael-type addition gelation kinetics for the generation of homogenous poly(ethylene glycol) hydrogels.
TL;DR: Although fast Michael-type addition crosslinked hydrogels appear uniform by bulk modulus readings and visual inspection, they are non-uniform in the micron scale, with high and low crosslinking regions that result in differences in cellular behavior.
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Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer.
Norman F. Truong,Evan Kurt,Nairi Tahmizyan,Sasha Cai Lesher-Perez,Mabel Chen,Nicole J. Darling,Weixian Xi,Tatiana Segura,Tatiana Segura +8 more
TL;DR: Investigating the effects of MAP physical and adhesion properties on cell spreading, proliferation, and gene transfer in fibroblasts finds that the void space size as well as the presentation of integrin ligands influence transfection efficiency.
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Injectable and Spatially Patterned Microporous Annealed Particle (MAP) Hydrogels for Tissue Repair Applications.
TL;DR: This injectable and spatially patterned hydrogel can be used to create physical or biochemical gradients and can better match the scaffold properties within the physical location of the tissue (e.g., wound border vs wound center).
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Click by Click Microporous Annealed Particle (MAP) Scaffolds.
Nicole J. Darling,Weixian Xi,Elias Sideris,Alexa R. Anderson,Cassie Pong,S. Thomas Carmichael,Tatiana Segura +6 more
TL;DR: Injection of porous HA‐Tet MAP scaffolds into an ischemic stroke model shows this chemistry is biocompatible in vivo with reduced levels of inflammation and astrogliosis as previously demonstrated for other crosslinking chemistries.