In situ forming injectable hydrogels for drug delivery and wound repair.
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TLDR
This review highlights injectable therapeutic hydrogel biomaterials in the context of drug delivery and tissue regeneration for skin wound repair and provides an avenue to minimally invasively deliver therapeutic payloads, fill complex tissue defects, and induce the regeneration of damaged portions of the body.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2018-03-01 and is currently open access. It has received 451 citations till now. The article focuses on the topics: Self-healing hydrogels & Drug delivery.read more
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Hydrogel microparticles for biomedical applications.
TL;DR: The techniques that are available for fabricating HMPs, as well as the multiscale behaviours of HMP systems and their functional properties are discussed, highlighting their advantages over traditional bulk hydrogels.
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Engineered biomaterials for in situ tissue regeneration
TL;DR: Two biomaterials approaches to control the regenerative capacity of the body for tissue-specific regeneration by modulating the extracellular microenvironment or driving cellular reprogramming are outlined.
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Translational Applications of Hydrogels.
Santiago Correa,Abigail K. Grosskopf,Hector Lopez Hernandez,Doreen Chan,Anthony C. Yu,Lyndsay M. Stapleton,Eric A. Appel +6 more
TL;DR: A review of the major capabilities of hydrogels, with a focus on the novel benefits of injectable hydrogel technologies, and how they relate to translational applications in medicine and the environment is presented in this paper.
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Nanoenzyme-Reinforced Injectable Hydrogel for Healing Diabetic Wounds Infected with Multidrug Resistant Bacteria.
TL;DR: The FEMI hydrogel demonstrated an accelerated MDR bacteria-infected diabetic wound healing in vivo and represents a versatile strategy for healing a broad range of tissue damages caused by diabetes.
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A Novel Double‐Crosslinking‐Double‐Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment
Lei Wang,Lei Wang,Xuehui Zhang,Kun Yang,Yu Vincent Fu,Tianshun Xu,Shengliang Li,Dawei Zhang,Lu-Ning Wang,Chun-Sing Lee +9 more
TL;DR: A novel hydrogel design is adopted by introducing two different chitosan chains via the simultaneous crosslinking of carbon–carbon double bonds and catechol‐Fe3+ chelation, which enhances mechanical performance including high compressive modulus and high ductility and can remarkably promote healing of bacteria‐infected wound.
References
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Alginate: properties and biomedical applications
Kuen Yong Lee,David J. Mooney +1 more
TL;DR: This review will provide a comprehensive overview of general properties of alginate and its hydrogels, their biomedical applications, and suggest new perspectives for future studies with these polymers.
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Highly stretchable and tough hydrogels
Jeong-Yun Sun,Xuanhe Zhao,Widusha R. K. Illeperuma,Ovijit Chaudhuri,Kyu Hwan Oh,David J. Mooney,David J. Mooney,Joost J. Vlassak,Zhigang Suo +8 more
TL;DR: The synthesis of hydrogels from polymers forming ionically and covalently crosslinked networks is reported, finding that these gels’ toughness is attributed to the synergy of two mechanisms: crack bridging by the network of covalent crosslinks, and hysteresis by unzipping thenetwork of ionic crosslinks.
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Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
TL;DR: The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl- L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronsectin and present in at least five other proteins.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
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Hydrogels in drug delivery: progress and challenges
Todd Hoare,Daniel S. Kohane +1 more
TL;DR: Recent progress in overcoming challenges with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs fromhydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches is discussed.