Nicole P. Bowles

TL;DR: The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms.

TL;DR: It is proposed that the physiologicalChanges observed in the high-CORT animals approximate changes observed in individuals suffering from the metabolic syndrome, and that they potentially serve as a model for hypercortisolemia and stress-related obesity.

TL;DR: The results show that sustained exposure to GCs produces obesity and metabolic syndrome through a peripheral endocannabinoid mechanism, and indicate that glucocorticoids recruit peripheral endOCannabinoid signaling to promote metabolic dysregulation, with hepatic endoc cannabinoid signaling being especially important for changes in lipid metabolism.

TL;DR: In general, nighttime administration of antihypertensives improved overall 24-h blood pressure profiles regardless of disease comorbidity, but inconsistencies between studies suggest a need for more prospective randomized controlled trials with sufficient statistical power.

TL;DR: Data demonstrate that the confounder of injection stress is sufficient to conceal the ability of protracted exposure to glucocorticoids to reduce CB(1) receptor density and augment AEA metabolism within limbic structures.