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Nicoletta Pedemonte
Researcher at Istituto Giannina Gaslini
Publications - 110
Citations - 4962
Nicoletta Pedemonte is an academic researcher from Istituto Giannina Gaslini. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Cystic fibrosis. The author has an hindex of 27, co-authored 84 publications receiving 4277 citations. Previous affiliations of Nicoletta Pedemonte include University of California, San Francisco & University of Genoa.
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TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
Antonella Caputo,Emanuela Caci,Loretta Ferrera,Nicoletta Pedemonte,Cristina Barsanti,Elvira Sondo,Ulrich Pfeffer,Roberto Ravazzolo,Olga Zegarra-Moran,Luis J. V. Galietta +9 more
TL;DR: Identification of a previously unknown family of membrane proteins associated with chloride channel function will improve the understanding of chloride transport physiopathology and allow for the development of pharmacological tools useful for basic research and drug development.
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Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening
Nicoletta Pedemonte,Gergely L. Lukacs,Kai Du,Emanuela Caci,Olga Zegarra-Moran,Luis J. V. Galietta,Alan S. Verkman +6 more
TL;DR: Screening of 150,000 chemically diverse compounds and more than 1,500 analogs of active compounds yielded several classes of DeltaF508-CFTR correctors with micromolar potency that produced greater apical membrane chloride current than did low-temperature rescue.
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Structure and Function of TMEM16 Proteins (Anoctamins)
TL;DR: A TMEM16 protein expressed in Aspergillus fumigatus displays both ion channel and lipid scramblase activity, which suggests that dual function is an ancestral characteristic of TM EM16 proteins and that some members, such as TMEM 16A and TMEM15B, have evolved to a pure channel function.
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High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening.
Tonghui Ma,L. Vetrivel,Hong Yang,Nicoletta Pedemonte,Olga Zegarra-Moran,Luis J. V. Galietta,Alan S. Verkman +6 more
TL;DR: The new activators identified here may be useful in defining molecular mechanisms of CFTR activation and as lead compounds in CF drug development.
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Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating
Hong Yang,Anang A. Shelat,R. Kiplin Guy,Vadiraj S. Gopinath,A. Tonghui Ma,Kai Du,Gergely L. Lukacs,Alessandro Taddei,Chiara Folli,Nicoletta Pedemonte,Luis J. V. Galietta,Alan S. Verkman +11 more
TL;DR: A Bayesian computational model was developed using tetrahydrobenzothiophene structure-activity data, yielding insight into the physical character and structural features of active and inactive potentiators and successfully predicting the activity of structural analogs.