Emanuela Caci

TL;DR: Identification of a previously unknown family of membrane proteins associated with chloride channel function will improve the understanding of chloride transport physiopathology and allow for the development of pharmacological tools useful for basic research and drug development.

TL;DR: Screening of 150,000 chemically diverse compounds and more than 1,500 analogs of active compounds yielded several classes of DeltaF508-CFTR correctors with micromolar potency that produced greater apical membrane chloride current than did low-temperature rescue.

TL;DR: In bronchial epithelial cells treated with interleukin‐4, it is found that TMEM16A protein becomes highly expressed in goblet but not in ciliated cells.

TL;DR: Measurements of H2O2 production at the apical surface of bronchial cells indicated that the extent of SCN− transport is important to modulate the conversion of this oxidant molecule by the lactoperoxidase system, which may be responsible for susceptibility to infections and/or decreased ability to scavenge oxidants.

TL;DR: The data suggest that IL-4 may favor the hydration of the airway surface by decreasing Na+ absorption and increasing Cl− secretion, which could be required to fluidify the mucus, which is hypersecreted during inflammatory conditions.