C
Chiara Folli
Researcher at Istituto Giannina Gaslini
Publications - 12
Citations - 1401
Chiara Folli is an academic researcher from Istituto Giannina Gaslini. The author has contributed to research in topics: Cystic fibrosis transmembrane conductance regulator & Chloride channel. The author has an hindex of 10, co-authored 12 publications receiving 1362 citations.
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Journal ArticleDOI
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion
Tonghui Ma,Jay R. Thiagarajah,Hong Yang,N.D. Sonawane,Chiara Folli,Luis J. V. Galietta,Alan S. Verkman +6 more
TL;DR: The most potent compound discovered by screening of structural analogs, CFTR(inh)-172, reversibly inhibited CFTR short-circuit current in less than 2 minutes in a voltage-independent manner with K(I) approximately 300 nM.
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Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating
Hong Yang,Anang A. Shelat,R. Kiplin Guy,Vadiraj S. Gopinath,A. Tonghui Ma,Kai Du,Gergely L. Lukacs,Alessandro Taddei,Chiara Folli,Nicoletta Pedemonte,Luis J. V. Galietta,Alan S. Verkman +11 more
TL;DR: A Bayesian computational model was developed using tetrahydrobenzothiophene structure-activity data, yielding insight into the physical character and structural features of active and inactive potentiators and successfully predicting the activity of structural analogs.
Journal ArticleDOI
IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro.
Luis J. V. Galietta,P. Pagesy,Chiara Folli,Emanuela Caci,Leila Romio,Bruno Costes,Elena Nicolis,Giulio Cabrini,Michel Goossens,Roberto Ravazzolo,Olga Zegarra-Moran +10 more
TL;DR: The data suggest that IL-4 may favor the hydration of the airway surface by decreasing Na+ absorption and increasing Cl− secretion, which could be required to fluidify the mucus, which is hypersecreted during inflammatory conditions.
Journal ArticleDOI
Altered channel gating mechanism for CFTR inhibition by a high‐affinity thiazolidinone blocker
Alessandro Taddei,Chiara Folli,Olga Zegarra-Moran,Pascale Fanen,Alan S. Verkman,Luis J. V. Galietta +5 more
TL;DR: The studies provide evidence for CFTR inhibition by CFTRinh‐172 by a mechanism involving altered CFTR gating by patch‐clamp and short‐circuit analysis using cells stably expressing wild‐type and mutant CFTRs.
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Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-γ
Luis J. V. Galietta,Chiara Folli,Carla Marchetti,Luca Romano,Daniela Carpani,Massimo Conese,Olga Zegarra-Moran +6 more
TL;DR: The results show that interferon-gamma alters the transepithelial ion transport of cultured bronchial cells and this effect may change the ion composition and/or volume of periciliary fluid.