N
Niels Decher
Researcher at University of Marburg
Publications - 113
Citations - 5891
Niels Decher is an academic researcher from University of Marburg. The author has contributed to research in topics: Potassium channel & Medicine. The author has an hindex of 35, co-authored 94 publications receiving 5156 citations. Previous affiliations of Niels Decher include University of Utah & Aventis Pharma.
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Journal ArticleDOI
Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Igor Splawski,Katherine W. Timothy,Leah M. Sharpe,Niels Decher,Pradeep Kumar,Raffaella Bloise,Carlo Napolitano,Peter J. Schwartz,Robert M. Joseph,Karen Condouris,Helen Tager-Flusberg,Silvia G. Priori,Michael C. Sanguinetti,Mark T. Keating +13 more
TL;DR: Functional expression reveals that G406R produces maintained inward Ca(2+) currents by causing nearly complete loss of voltage-dependent channel inactivation, which likely induces intracellular Ca( 2+) overload in multiple cell types.
Journal ArticleDOI
Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations
Igor Splawski,Katherine W. Timothy,Katherine W. Timothy,Niels Decher,Pradeep Kumar,Frank B. Sachse,Alan H. Beggs,Michael C. Sanguinetti,Mark T. Keating,Mark T. Keating +9 more
TL;DR: In this article, the authors identified de novo missense mutations in exon 8 of the spliced form of CaV1.2 in both individuals, which resulted in extreme prolongation of the QT interval on electrocardiogram.
Journal ArticleDOI
DCPIB is a novel selective blocker of ICl,swell and prevents swelling‐induced shortening of guinea‐pig atrial action potential duration
Niels Decher,Lang Hans Jochen,Bernd Nilius,Andrea Brüggemann,Andreas E. Busch,Klaus Steinmeyer +5 more
TL;DR: It is concluded that swelling‐induced AP shortening in isolated atrial cells is mainly caused by activation of ICl,swell, and DCPIB is a valuable pharmacological tool to study the role of I Cl, Swell in cardiac excitability under pathophysiological conditions leading to cell swelling.
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The pore structure and gating mechanism of K2P channels: K2P channel gating
Paula L. Piechotta,Markus Rapedius,Phillip J. Stansfeld,Murali K. Bollepalli,Gunter Erhlich,Isabelle Andres-Enguix,Hariolf Fritzenschaft,Niels Decher,Mark S.P. Sansom,Stephen J. Tucker,Thomas Baukrowitz +10 more
TL;DR: In this paper, quaternary ammonium (QA) ions bind with high affinity deep within the pore of TREK-1 and have free access to their binding site before channel activation by intracellular pH or pressure.
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The acid-sensitive potassium channel TASK-1 in rat cardiac muscle.
C. Putzke,Konstantin Wemhöner,Frank B. Sachse,Susanne Rinné,Günter Schlichthörl,Xian Tao Li,Lucas T. Jae,Ines Eckhardt,Erhard Wischmeyer,Hinnerk Wulf,Regina Preisig-Müller,Jürgen Daut,Niels Decher +12 more
TL;DR: It is suggested that in rat cardiomyocytes I(TASK) makes a substantial contribution to the outward current flowing in the plateau range of potentials and that this current component can be inhibited via alpha1A-adrenergic receptors.