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Niels H.H. Heegaard
Researcher at National Institutes of Health
Publications - 9
Citations - 1112
Niels H.H. Heegaard is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Affinity electrophoresis & Gel electrophoresis. The author has an hindex of 6, co-authored 9 publications receiving 1036 citations. Previous affiliations of Niels H.H. Heegaard include University of Copenhagen.
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Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
TL;DR: A general overview of the connection between inflammation, microRNAs and cancer is provided and how improved understanding of these connections may provide novel preventive, diagnostic and therapeutic strategies to reduce the health burden of cancer is highlighted.
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Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer.
Niels H.H. Heegaard,Aaron J. Schetter,Judith A. Welsh,Mitsuhiro Yoneda,Elise D. Bowman,Curtis C. Harris +5 more
TL;DR: Find evidence that expression of let‐7b is associated with prognosis in NSCLC and methods to accurately and reproducibly measure micro‐RNA levels in serum and plasma find significant differences in miR expression when comparing cases and controls.
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Use of capillary zone electrophoresis to evaluate the binding of anionic carbohydrates to synthetic peptides derived from human serum amyloid P component
TL;DR: It should be possible to use electrophoretic separation in capillaries to evaluate the binding of peptides to any ligand as long as the differences in charge/mass ratio between free and complexed peptide are of a sufficient magnitude as in the peptide-heparin binding demonstrated here.
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Use of capillary zone electrophoresis for the analysis of DNA-binding to a peptide derived from amyloid P component
TL;DR: Capillary zone electrophoresis was used to characterize the binding interactions between oligonucleotides and synthetic peptides derived from human serum amyloid P component, applicable for any molecular interaction where the charge/mass ratio of complexes differ from the free molecules.
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A capillary electrophoresis-based assay for the binding of Ca2+ and phosphorylcholine to human C-reactive protein.
TL;DR: Capillary capillary electrophoresis is generally useful to study interactions where complexed molecules display an electrophoretic mobility that is different from that of unbound molecules and where the rates of association and dissociation are sufficiently fast.