N
Niina Reunanen
Researcher at University of Turku
Publications - 6
Citations - 591
Niina Reunanen is an academic researcher from University of Turku. The author has contributed to research in topics: MAPK/ERK pathway & Protein kinase A. The author has an hindex of 6, co-authored 6 publications receiving 578 citations.
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Journal ArticleDOI
Activation of p38α MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization
TL;DR: Two distinct and complementary signaling mechanisms mediating induction of M MP-1 and MMP-3 expression in dermal fibroblasts are identified: AP-1-dependent transcriptional activation via the ERK1/2 pathway and AP- 1-independent enhancement via p38α MAPK by mRNA stabilization.
Journal ArticleDOI
Enhancement of Fibroblast Collagenase (Matrix Metalloproteinase-1)Gene Expression by Ceramide Is Mediated by Extracellular Signal-regulated and Stress-activated Protein Kinase Pathways
Niina Reunanen,Jukka Westermarck,Lari Häkkinen,Tim H. Holmström,Iina Elo,John E. Eriksson,Veli-Matti Kähäri +6 more
TL;DR: Results show that triggering the ceramide signaling pathway activates MMP-1 gene expression via three distinct MAPK pathways, i.e. ERK1/2, SAPK/JNK, and p38, and suggest that targeted modulation of the ceramic signaling pathway may offer a novel therapeutic approach for inhibiting collagenolytic activity, e.g. in inflammatory disorders.
Journal ArticleDOI
Expression of collagenase-3 (matrix metalloproteinase-13) in transitional-cell carcinoma of the urinary bladder
Peter J. Boström,Laura Ravanti,Niina Reunanen,Vesa Aaltonen,Karl-Ove Söderström,Veli-Matti Kähäri,Matti Laato +6 more
TL;DR: MMP‐13 expression in human urinary bladder carcinoma cells in vivo and in vitro is demonstrated and it is suggested that M MP‐13 may serve as a marker for transformation and invasion in urinary bladder TCCs.
Journal ArticleDOI
Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts.
TL;DR: The results identify the ERK1/2 signaling cascade as a potent negative regulatory pathway with respect to type I collagen expression in fibroblasts, suggesting that it mediates inhibition of collagen production in response to mitogenic stimulation and transformation.