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Nikolaus Wenger
Researcher at Charité
Publications - 25
Citations - 2101
Nikolaus Wenger is an academic researcher from Charité. The author has contributed to research in topics: Spinal cord injury & Neuromodulation (medicine). The author has an hindex of 13, co-authored 22 publications receiving 1611 citations. Previous affiliations of Nikolaus Wenger include Austrian Academy of Sciences & Humboldt University of Berlin.
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Journal ArticleDOI
Electronic dura mater for long-term multimodal neural interfaces
Ivan R. Minev,Pavel Musienko,Arthur Hirsch,Quentin Barraud,Nikolaus Wenger,Eduardo Martin Moraud,Jerome Gandar,Marco Capogrosso,Tomislav Milekovic,Leonie Asboth,Rafael Fajardo Torres,Nicolas Vachicouras,Nicolas Vachicouras,Qihan Liu,N. V. Pavlova,Simone Duis,Alexandre Larmagnac,Janos Vörös,Silvestro Micera,Silvestro Micera,Zhigang Suo,Grégoire Courtine,Stéphanie P. Lacour +22 more
TL;DR: In this paper, the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord, was designed and fabricated for implantable neuroprostheses, which embeds interconnects, electrodes and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections.
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A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits
Marco Capogrosso,Marco Capogrosso,Nikolaus Wenger,Stanisa Raspopovic,Stanisa Raspopovic,Pavel Musienko,Janine Beauparlant,Lorenzo Bassi Luciani,Grégoire Courtine,Silvestro Micera,Silvestro Micera +10 more
TL;DR: A computational model and in vivo experiments were designed and performed to investigate the type of fibers, neurons, and circuits recruited in response to EES to provide a mechanistic framework for the design of spinal neuroprosthetic systems to improve standing and walking after neurological disorders.
Journal ArticleDOI
Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury
Nikolaus Wenger,Nikolaus Wenger,Eduardo Martin Moraud,Jerome Gandar,Pavel Musienko,Marco Capogrosso,Marco Capogrosso,Laetitia Baud,Camille G. Le Goff,Quentin Barraud,N. V. Pavlova,Nadia Dominici,Nadia Dominici,Ivan R. Minev,Leonie Asboth,Arthur Hirsch,Simone Duis,Julie Kreider,Andrea Mortera,Oliver Haverbeck,Silvio Kraus,Felix Schmitz,Jack DiGiovanna,Rubia van den Brand,Jocelyne Bloch,Peter Detemple,Stéphanie P. Lacour,Erwan Bezard,Erwan Bezard,Silvestro Micera,Silvestro Micera,Grégoire Courtine,Grégoire Courtine +32 more
TL;DR: Spatiotemporal neuromodulation therapies improved gait quality, weight-bearing capacity, endurance and skilled locomotion in several rodent models of spinal cord injury and are directly translatable to strategies to improve motor control in humans.
Journal ArticleDOI
Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury
Nikolaus Wenger,Eduardo Martin Moraud,Stanisa Raspopovic,Marco Bonizzato,Jack DiGiovanna,Pavel Musienko,Manfred Morari,Silvestro Micera,Silvestro Micera,Grégoire Courtine +9 more
TL;DR: A closed-loop system that will essentially “auto-tune” the neuromodulation device, allowing the paralyzed patient—or, in their study, the paralyzed rat—to move freely, without worrying about adjusting electrical pulse width, amplitude, or frequency is created.
Journal ArticleDOI
Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury.
Eduardo Martin Moraud,Marco Capogrosso,Emanuele Formento,Nikolaus Wenger,Jack DiGiovanna,Grégoire Courtine,Silvestro Micera,Silvestro Micera +7 more
TL;DR: Using computer simulations and behavioral experiments, evidence is provided that epidural electrical stimulation interacts with muscle spindle feedback circuits to modulate muscle activity during locomotion and provides a conceptual framework to improve stimulation protocols for clinical applications.