Simone Duis

TL;DR: In this paper, the shape and elasticity of dura mater, the protective membrane of the brain and spinal cord, was designed and fabricated for implantable neuroprostheses, which embeds interconnects, electrodes and chemotrodes that sustain millions of mechanical stretch cycles, electrical stimulation pulses, and chemical injections.

TL;DR: An electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally mediated movements in rats with paralyzing lesions triggered a cortex-dependent recovery that may improve function after similar injuries in humans.

TL;DR: The implantable components integrated in the brain–spine interface have all been approved for investigational applications in similar human research, suggesting a practical translational pathway for proof-of-concept studies in people with spinal cord injury.

TL;DR: Spatiotemporal neuromodulation therapies improved gait quality, weight-bearing capacity, endurance and skilled locomotion in several rodent models of spinal cord injury and are directly translatable to strategies to improve motor control in humans.

TL;DR: Robust task-specific neuronal population responses revealed that the rat motor cortex displays similar modulation as other mammals during locomotion, which emphasizes the importance of the behavioral procedure to engage the motor cortex during motor control studies, gait rehabilitation, and locomotor neuroprosthetic developments in rats.